Radioiodinated aza-diphenylacetylenes as potential SPECT imaging agents for β-amyloid plaque detection
- Author
- WENCHAO QU1 ; KUNG, Mei-Ping1 ; HOU, Catherine1 ; JIN, Lee-Way2 ; KUNG, Hank F1 3
[1] Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, United States
[2] Department of Pathology, University of California Health System, Sacramento, CA 95817, United States
[3] Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 13, pp 3581-3584, 4 p ; ref : 20 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Alzheimer's disease Autoradiography and Sonogashira coupling reaction Biodistribution Radioiodination
- Keyword (fr)
- Agent scintigraphique Amine aromatique Aniline dérivé Animal Autoradiographie Barrière hématoencéphalique Composé acétylénique Distribution Démence Alzheimer Encéphale Ethylène oxyde polymère Fixation biologique Formation image Homme In vitro In vivo Iode 125 Iode Isotope Ligand Marquage radioisotopique Matériel autopsie Normal Oligomère Pharmacocinétique Postmortem Protéine amyloïde β Pyridine dérivé Souris Synthèse chimique Système nerveux central Tissu Voie intraveineuse Biodistribution Copulation Sonogashira Ethanol2-[5-([4-(diméthylamino)phényl]éthynyl)-3-iodo-2-pyridyloxy] Radioiodation Radioligand Fluor composé organique Mammalia Rodentia Vertebrata
- Keyword (en)
- Scintigraphic agent Aromatic amine Aniline derivatives Animal Autoradiography Blood brain barrier Acetylenic compound Distribution Alzheimer disease Encephalon Ethylene oxide polymer Biological fixation Imaging Human In vitro In vivo Iodine 125 Iodine Isotopes Ligand Radiolabelling Autopsy material Normal Oligomer Pharmacokinetics Postmortem β Amyloid protein Pyridine derivatives Mouse Chemical synthesis Central nervous system Tissue Intravenous administration Organic fluorine compounds Mammalia Rodentia Vertebrata
- Keyword (es)
- Agente centelleográfico Amina aromática Anilina derivado Animal Autorradiografía Barrera hematoencefálica Compuesto acetilénico Distribución Demencia Alzheimer Encéfalo Etileno óxido polímero Fijación biológica Formación imagen Hombre In vitro In vivo Iodo Isótopo Ligando Marcación radioisotópica Material autopsia Normal Oligómero Farmacocinética Postmortem Proteína amiloide β Piridina derivado Ratón Síntesis química Sistema nervioso central Tejido Vía intravenosa Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02T Contrast media. Radiopharmaceuticals
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18859546
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2007.04.062 
https://dx.doi.org/10.1016/j.bmcl.2007.04.062
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