Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
- Author
- PARKES, Miles1 ; BARRETT, Jeffrey C2 ; DRUMMOND, Hazel4 ; LEES, Charlie W4 ; KHAWAJA, Saud A3 ; BAGNALL, Richard3 ; BURKE, Denis A6 ; TODHUNTER, Catherine E6 ; AHMAD, Tariq5 ; ONNIE, Clive M3 ; MCARDLE, Wendy7 ; STRACHAN, David8 ; PRESCOTT, Natalie J3 ; BETHEL, Graeme9 ; BRYAN, Claire9 ; LEWIS, Cathryn M3 ; DELOUKAS, Panos9 ; FORBES, Alastair10 ; SANDERSON, Jeremy11 ; JEWELL, Derek P5 ; SATSANGI, Jack4 ; MANSFIELD, John C6 ; CARDON, Lon2 ; TREMELLING, Mark1 ; MATHEW, Christopher G3 ; ANDERSON, Carl A2 ; FISHER, Sheila A3 ; ROBERTS, Roland G3 ; NIMMO, Elaine R4 ; CUMMINGS, Fraser R5 ; SOARS, Dianne3
[1] Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
[2] Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford 0X3 7BN, United Kingdom
[3] Department of Medical and Molecular Genetics, King's College London School of Medicine, Guy's Hospital, London, SE1 9RT, United Kingdom
[4] Gastrointestinal Unit, Division of Medical Sciences, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
[5] Gastroenterology Unit, Radcliffe Infirmary, University of Oxford, Oxford 0X2 6HE, United Kingdom
[6] Department of Gastroenterology and Hepatology, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom
[7] Avon Longitudinal Study of Parents and Children (ALSPAC), University of Bristol, 24 Tyndall Avenue, Bristol, BS8 1TQ, United Kingdom
[8] Division of Community Health Services, St George's University of London, Cranmer Terrace, London SW17 0RE, United Kingdom
[9] The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
[10] Institute for Digestive Diseases, University College London Hospitals Trust, London NW1 2BU, United Kingdom
[11] Department of Gastroenterology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, United Kingdom
Wellcome Trust Case Control Consortium, United Kingdom - Source
Nature genetics. 2007, Vol 39, Num 7, pp 830-832, 3 p ; ref : 15 ref
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Entérite Crohn Gène Locus Variant Association génétique Autophagie Appareil digestif pathologie Intestin pathologie Maladie inflammatoire
- Keyword (en)
- Crohn disease Gene Locus Variant Autophagy Digestive diseases Intestinal disease Inflammatory disease
- Keyword (es)
- Enteritis Crohn Gen Locus Variante Autofagia Aparato digestivo patología Intestino patología Enfermedad inflamatoria
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13B Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / 002B13B03 Other diseases. Semiology
- Discipline
- Eukaryotes genetics. Biological and molecular evolution Gastroenterology. Liver. Pancreas. Abdomen
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18870210
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/ng2061 
https://dx.doi.org/10.1038/ng2061
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