Thiophene-anthranilamides as highly potent and orally available factor xa inhibitors
- Author
- BIN YE1 ; ARNAIZ, Damian O1 ; WU, Shung C1 ; ZUCHUN ZHAO1 ; ADLER, Marc1 ; CHEESEMAN, Sarah1 ; DOLE, William P1 ; EWING, Janice1 ; FITCH, Richard1 ; LENTZ, Dao1 ; LIANG, Amy1 ; LIGHT, David1 ; CHOU, Yuo-Ling1 ; MORSER, John2 ; POST, Joseph2 ; RUMENNIK, Galina2 ; SUBRAMANYAM, Babu2 ; SULLIVAN, Mark E2 ; VERGONA, Ron2 ; WALTERS, Janette2 ; WANG, Yi-Xin2 ; WHITE, Kathy A2 ; WHITLOW, Marc2 ; GRIEDEL, Brian D1 ; KOCHANNY, Monica J2 ; KARANJAWALA, Rushad1 ; LEE, Wheeseong1 ; MORRISSEY, Michael M1 ; SACCHI, Karna L1 ; SAKATA, Steven T1 ; SHAW, Kenneth J1
[1] Berlex Biosciences, Post Office Box 4099, Richmond, California 94804-0099, United States
[2] Berlex Biosciences, Post Office Box 4099, Richmond, California 94804-0099, United States - Source
Journal of medicinal chemistry (Print). 2007, Vol 50, Num 13, pp 2967-2980, 14 p ; ref : 24 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Anticoagulant Antithrombotique Chien Chlore composé organique Coagulation Factor Xa Homme In vitro In vivo Inhibiteur enzyme Oxazole dérivé Pharmacocinétique Pyridine dérivé Rat Relation structure activité Synthèse chimique Thiophène dérivé Voie orale Anthranilamide dérivé Inhibiteur coagulation factor XA Thiophène-2-carboxamide dérivé Carnivora Enzyme Fissipedia Hydrolases Mammalia Peptidases Rodentia Serine endopeptidases Vertebrata
- Keyword (en)
- Animal Anticoagulant Antithrombotic agent Dog Organic chlorine compounds Coagulation Factor Xa Human In vitro In vivo Enzyme inhibitor Oxazole derivatives Pharmacokinetics Pyridine derivatives Rat Structure activity relation Chemical synthesis Thiophene derivatives Oral administration Carnivora Enzyme Fissipedia Hydrolases Mammalia Peptidases Rodentia Serine endopeptidases Vertebrata
- Keyword (es)
- Animal Anticoagulante antitrombōtico Perro Coagulation Factor Xa Hombre In vitro In vivo Inhibidor enzima Oxazol derivado Farmacocinética Piridina derivado Rata Relación estructura actividad Síntesis química Tiofeno derivado Vía oral Carnivora Enzima Fissipedia Hydrolases Mammalia Peptidases Rodentia Serine endopeptidases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02G Blood. Blood coagulation. Reticuloendothelial system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18898254
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm070125f 
https://dx.doi.org/10.1021/jm070125f
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