Design and synthesis of classical and nonclassical 6 -arylthio -2,4 -diamino-5-ethylpyrrolo [2,3-d]pyrimidines as antifolates
- Author
- GANGJEE, Aleem1 ; YIBIN ZENG1 ; TALREJA, Tina1 ; MCGUIRE, John J2 ; KISLIUK, Roy L3 ; QUEENER, Sherry F4
[1] Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, United States
[2] Grace Cancer Drug Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, United States
[3] Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, United States
[4] Department of Pharmacology and Toxicology, School of Medicine, Indiana University, 635 Barnhill Drive, Indianapolis, 46202 Indiana, United States - Source
Journal of medicinal chemistry (Print). 2007, Vol 50, Num 13, pp 3046-3053, 8 p ; ref : 21 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antibactérien Antifolate Antimétabolite Antiparasitaire Cellule tumorale Dihydrofolate reductase In vitro Lignée cellulaire Mycobacterium avium Relation structure activité Synthèse chimique Toxoplasma gondii Glutamique acide dérivé Pyrrolo[2,3-d]pyrimidine dérivé Pyrrolo[2,3-d]pyrimidine(6-arylsulfanyl-2,4-diamino-5-éthyl) Pyrrolopyrimidine Actinomycetes Apicomplexa Bactérie Enzyme Mycobacteriaceae Mycobacteriales Oxidoreductases Protozoa
- Keyword (en)
- Antibacterial agent Antifolate Antimetabolic Parasiticide Tumor cell Dihydrofolate reductase In vitro Cell line Mycobacterium avium Structure activity relation Chemical synthesis Toxoplasma gondii Actinomycetes Apicomplexa Bacteria Enzyme Mycobacteriaceae Mycobacteriales Oxidoreductases Protozoa
- Keyword (es)
- Antibacteriano Antifolato Antimetabólito Antiparasitario Célula tumoral Dihydrofolate reductase In vitro Línea celular Mycobacterium avium Relación estructura actividad Síntesis química Toxoplasma gondii Actinomycetes Apicomplexa Bacteria Enzima Mycobacteriaceae Mycobacteriales Oxidoreductases Protozoa
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S02 Antibacterial agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S06 Antiparasitic agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18898261
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm070165j 
https://dx.doi.org/10.1021/jm070165j
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