Pyridazinoquinolinetriones as NMDA glycine-site antagonists with oral antinociceptive activity in a model of neuropathic pain
- Author
- BARE, Thomas M1 ; BROWN, Dean G1 ; HERZOG, Keith J1 ; KEITH, Richard A1 ; KIRSCHNER, Alan S1 ; LEE, Chi-Ming C1 ; LEWIS, Joseph1 ; MCLAREN, Frances M1 ; NEILSON, Kathy L1 ; STEELMAN, Gary B1 ; TRIVEDI, Shephali1 ; VACEK, Edward P1 ; HORCHLER, Carey L1 ; WENHUA XIAO2 ; MURPHY, Megan1 ; URBANEK, Rebecca A1 ; ALFORD, Vernon1 ; BARLAAM, Christine1 ; DYROFF, Martin C1 ; EMPFIELD, James B1 ; FORST, Janet M1
[1] AstraZeneca Pharmaceuticals LP, 1800 Concord Pike, Wilmington, Delaware 19803, United States
[2] AstraZeneca Pharmaceuticals LP, 1800 Concord Pike, Wilmington, Delaware 19803, United States - Source
Journal of medicinal chemistry (Print). 2007, Vol 50, Num 13, pp 3113-3131, 19 p ; ref : 36 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Analgésique Antagoniste Chlore composé organique Douleur Hydrosolubilité In vitro In vivo Modèle Neuropathie périphérique Névralgie Propriété physicochimique Relation structure activité Récepteur NMDA Récepteur glutamate Récepteur glycine Urées Voie orale Pyridazino[4,5-b]quinoléine dérivé Pyridazino[4,5-b]quinoléine-1,4,10-trione dérivé Pyridazinoquinoléine Nerf périphérique pathologie Système nerveux pathologie Trouble neurologique
- Keyword (en)
- Analgesic Antagonist Organic chlorine compounds Pain Water solubility In vitro In vivo Models Peripheral neuropathy Neuralgia Physicochemical properties Structure activity relation NMDA receptor Glutamate receptor Glycine receptor Ureas Oral administration Peripheral nerve disease Nervous system diseases Neurological disorder
- Keyword (es)
- Analgésico Antagonista Dolor Hidrosolubilidad In vitro In vivo Modelo Neuropatía periférica Neuralgia Propiedad fisicoquímica Relación estructura actividad Receptor NMDA Receptor glutámato Receptor glicina Ureas Vía oral Nervio periférico patología Sistema nervioso patología Trastorno neurológico
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B05 Analgesics
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09E Glutamatergic system (aspartate and other excitatory aminoacids)
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18898268
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm060212s 
https://dx.doi.org/10.1021/jm060212s
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