Development and validation of a sensitive solid-phase extraction and high-performance liquid chromatographic assay for the novel bio-reductive anti-tumor agent RH1 in human and mouse plasma
- Author
- KHAN, P1 ; ABBAS, S1 ; HARGREAVES, R. H. J1 ; CAFFREY, R1 ; MEGRAM, V1 ; MCGOWN, A1
[1] Paterson Institute for Cancer Research, Section of Drug Development and Imaging, Christie Hospital NHS Trust, Wilmslow Road., Withington, Manchester M20 4BX, United Kingdom - Source
Journal of chromatography. B, Biomedical sciences and applications. 1999, Vol 729, Num 1-2, pp 287-295 ; ref : 11 ref
- ISSN
- 1387-2273
- Scientific domain
- Biochemistry, molecular biology, biophysics; Medical laboratory techniques
- Publisher
- Elsevier Science, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Keyword (fr)
- Analyse chimique Analyse quantitative Animal Anticancéreux Benzoquinone dérivé Chromatographie HPLC Chromatographie phase inverse Détecteur UV Extraction SPE Homme Liquide biologique Médicament activé par bioréduction Méthode analyse Pharmacocinétique Plasma sanguin Sang total Sang Souris RH1 Mammalia Rodentia Vertebrata
- Keyword (en)
- Chemical analysis Quantitative analysis Animal Antineoplastic agent Benzoquinone derivatives HPLC chromatography Reversed phase chromatography Ultraviolet detector Solid phase extraction Human Biological fluid Bioreductive drug Analysis method Pharmacokinetics Blood plasma Whole blood Blood Mouse Mammalia Rodentia Vertebrata
- Keyword (es)
- Análisis químico Análisis cuantitativo Animal Anticanceroso Benzoquinona derivado Cromatografía HPLC Cromatografía fase inversa Detector UV Extracción SPE Hombre Líquido biológico Medicamento activado por bioreducción Método análisis Farmacocinética Plasma sanguíneo Sangre total Sangre Ratón Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A02 Analysis
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 1892618
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/S0378-4347(99)00177-2 
https://dx.doi.org/10.1016/S0378-4347(99)00177-2
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