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A novel thrombin binding aptamer containing a G-LNA residue

Author
VIRNO, Ada1 ; RANDAZZO, Antonio1 ; GIANCOLA, Concetta2 ; BUCCI, Mariarosaria3 ; CIRINO, Giuseppe3 ; MAYOL, Luciano1
[1] Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, via D. Montesano 49, 80131 Napoli, Italy
[2] Dipartimento di Chimica, Università degli Studi di Napoli Federico II, via Cintia, 80126, Napoli, Italy
[3] Dipartimento di Farmacologia Sperimentale, Università degli Studi di Napoli Federico II, via D. Montesano 49, 80131 Napoli, Italy
Source

Bioorganic & medicinal chemistry. 2007, Vol 15, Num 17, pp 5710-5718, 9 p ; ref : 42 ref

ISSN
0968-0896
Scientific domain
Biochemistry, molecular biology, biophysics; Pharmacology drugs
Publisher
Elsevier Science, Oxford
Publication country
United Kingdom
Document type
Article
Language
English
Author keyword
Anticoagulant activity DNA LNA NMR Quadruplex TBA
Keyword (fr)
Activité biologique Analyse thermodynamique Anticoagulant Changement conformation DNA Dynamique conformationnelle Etude théorique Modèle 3 dimensions Modélisation Méthode dynamique moléculaire Oligonucléotide antisens Pliage Spectrométrie CD Spectrométrie RMN Spécificité séquence Synthèse chimique Séquence nucléotide Thrombin Télomère Aptamère Quadruplexe Enzyme Hydrolases Peptidases Serine endopeptidases
Keyword (en)
Biological activity Thermodynamic analysis Anticoagulant Conformational changes DNA Conformational dynamics Theoretical study Three dimensional model Modeling Molecular dynamics method Antisense oligonucleotide Folding Circular dichroism spectrometry NMR spectrometry Sequence specificity Chemical synthesis Nucleotide sequence Thrombin Telomere Enzyme Hydrolases Peptidases Serine endopeptidases
Keyword (es)
Actividad biológica Análisis termodinámico Anticoagulante DNA Dinámica conformacional Estudio teórico Modelo 3 dimensiones Modelización Método dinámico molecular Oligonucleótido antisentido Doblado Espectrometría CD Espectrometría RMN Espicificidad secuencia Síntesis química Secuencia nucleótido Thrombin Telómero Enzima Hydrolases Peptidases Serine endopeptidases
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02G Blood. Blood coagulation. Reticuloendothelial system

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
18928768

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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