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Inhibition of nuclear factor-κB activity by temozolomide involves O6-methylguanine -induced inhibition of p65 DNA binding

Author
YAMINI, Bakhtiar1 ; XIAOHONG YU1 ; EILEEN DOLAN, M2 ; WU, Michael H2 ; KUFE, Donald W3 ; WEICHSELBAUM, Ralph R4
[1] Section of Neurosurgery, Department of Surgery, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, United States
[2] Section of Hematology/Oncology, Department of Medicine, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, United States
[3] Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, Massachusetts, United States
[4] Department of Radiation and Cellular Oncology, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, United States
Source

Cancer research (Baltimore). 2007, Vol 67, Num 14, pp 6889-6898, 10 p ; ref : 50 ref

CODEN
CNREA8
ISSN
0008-5472
Scientific domain
Medical oncology; Pharmacology drugs
Publisher
American Association for Cancer Research, Philadelphia, PA
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Activité biologique Adduit moléculaire Anticancéreux DNA Facteur transcription NFκB Inhibiteur Mécanisme action Témozolomide Guanine(6-O-méthyl) Agent alkylant
Keyword (en)
Biological activity Molecular adduct Antineoplastic agent DNA Transcription factor NFκB Inhibitor Mechanism of action Temozolomide Alkylating agent
Keyword (es)
Actividad biológica Producto adición molecular Anticanceroso DNA Factor transcripción NFκB Inhibidor Mecanismo acción Temozolomida Agente alquilante
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
18940029

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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