Collateral damage of flomoxef therapy : in vivo development of porin deficiency and acquisition of bla_DHA-1 leading to ertapenem resistance in a clinical isolate of Klebsiella pneumoniae producing CTX-M-3 and SHV-5 β-lactamases

Author

LEE, Chen-Hsiang¹ ; CHU, Chishih² ; LIU, Jien-Wei¹ ; CHEN, Yi-Shung² ; CHIU, Chiung-Jung² ; SU, Lin-Hui^{3 4}
[1] Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan, Province of China
[2] Department of Applied Microbiology, National Chiayi University, 300 University Road, Chiayi 600, Taiwan, Province of China
[3] Department of Clinical Pathology, Lin-Kou Medical Center, Chang Gung Memorial Hospital, 5 Fu-Hsin Street, Kweishan, Taoyuan 333, Taiwan, Province of China
[4] Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, 259 Wenhua 1st Road, Kweishan, Taoyuan 333, Taiwan, Province of China

Source

Journal of antimicrobial chemotherapy (Print). 2007, Vol 60, Num 2, pp 410-413, 4 p ; ref : 10 ref

CODEN

JACHDX

ISSN

0305-7453

Scientific domain

Microbiology, infectious diseases; Pharmacology drugs

Publisher

Oxford University Press, Oxford

Publication country

United Kingdom

Document type

Article

Language

English

Author keyword

OMPs antimicrobial resistance mechanisms carbapenems outer membrane proteins

Keyword (fr)

Antibactérien Antibiotique Antimicrobien Carbapénème dérivé Déficit Ertapénem Flomoxef Homme In vivo Isolat clinique Klebsiella pneumoniae Lésion Membrane externe Mécanisme action Porine Protéine membranaire Résistance Test sensibilité médicamenteuse Traitement β-Lactamase Bactérie Céphalosporine dérivé Enterobacteriaceae Enzyme Hydrolases β-Lactamines

Keyword (en)

Antibacterial agent Antibiotic Antimicrobial agent Carbapenem derivatives Deficiency Ertapenem Flomoxef Human In vivo Clinical isolate Klebsiella pneumoniae Lesion External membrane Mechanism of action Porin Membrane protein Resistance Drug susceptibility test Treatment β-Lactamase Bacteria Cephalosporin derivatives Enterobacteriaceae Enzyme Hydrolases β-Lactams

Keyword (es)

Antibacteriano Antibiótico Antimicrobiano Carbapenem derivado Déficiencia Ertapenem Flomoxef Hombre In vivo Aislado clinico Klebsiella pneumoniae Lesión Membrana externa Mecanismo acción Porina Proteína membranar Resistencia Prueba sensibilidad medicamentosa Tratamiento β-Lactamase Bacteria Cefalosporina derivado Enterobacteriaceae Enzima Hydrolases β-Lactams

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents

Discipline

Pharmacological treatments

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

18959321

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS