Mechanism-based design of Inosine 5'-monophosphate dehydrogenase inhibitors : Synthesis and biological activities of 5-ethynyl-1-β-d-ribofuranosylimidazole-4-carboxamide (EICAR) and its derivatives
- Author
- MINAKAWA, N1 ; MATSUDA, A1
[1] Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan - Issue title
- Inhibition of inosine monophosphate dehydrogenase (IMPDH)
- Author (monograph)
- PANKIEWICZ, Krzysztof W (Editor)
- Source
Current medicinal chemistry. 1999, Vol 6, Num 7, pp 615-628 ; ref : 54 ref
- ISSN
- 0929-8673
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Bentham Science, Schiphol
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anticancéreux Antiviral Article synthèse Cellule tumorale Composé acétylénique Homme IMP dehydrogenase Imidazole dérivé In vitro In vivo Inhibiteur enzyme Mécanisme action Nucléoside Relation structure activité Synthèse chimique Tumeur maligne Tumeur solide Imidazole-4-carboxylique acide(5-éthynyl-1-[β-D-ribofuranosyl]) amide Enzyme Oxidoreductases
- Keyword (en)
- Antineoplastic agent Antiviral Review Tumor cell Acetylenic compound Human IMP dehydrogenase Imidazole derivatives In vitro In vivo Enzyme inhibitor Mechanism of action Nucleoside Structure activity relation Chemical synthesis Malignant tumor Solid tumor Enzyme Oxidoreductases
- Keyword (es)
- Anticanceroso Antiviral Artículo síntesis Célula tumoral Compuesto acetilénico Hombre IMP dehydrogenase Imidazol derivado In vitro In vivo Inhibidor enzima Mecanismo acción Nucleósido Relación estructura actividad Síntesis química Tumor maligno Tumor sólido Enzima Oxidoreductases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 1898309
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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