Design of noncompetitive inierleukin-8 inhibitors acting on CXCR1 and CXCR2
- Author
- MORICONI, Alessio1 ; CESTA, Maria Candida1 ; GALLIERA, Emanuela2 ; DI BENEDETTO, Paola1 ; VIGILANTE, Paolo1 ; BERTINI, Riccardo1 ; ALLEGRETTI, Marcello1 ; CERVELLERA, Maria Neve1 ; ARAMINI, Andrea1 ; CONIGLIO, Silvia1 ; COLAGIOIA, Sandro1 ; BECCARI, Andrea Rosario1 ; BIZZARRI, Cinzia1 ; CAVICCHIA, Michela Rita1 ; LOCATI, Massimo2 3
[1] Research Centre, Dompé pha.r.ma s.p.a., via Campo di Pile, 67100, L'Aquila, Italy
[2] Institute of General Pathology, University of Milan, 20133 Milan, Italy
[3] Istituto Clinico Humanitas, 20089 Rozzano, Italy - Source
Journal of medicinal chemistry (Print). 2007, Vol 50, Num 17, pp 3984-4002, 19 p ; ref : 54 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide carboxylique Affinité Antagoniste Antiinflammatoire Dérivé de l'acide arylpropionique Homme In vitro Inhibiteur allostérique Interleukine 8 Leucocyte Macrophage Modèle moléculaire Modélisation Relation structure activité Récepteur chimiokine CXCR1 Récepteur chimiokine CXCR2 Sulfonate Synthèse chimique Propionamide(2-[4-(trifluoromésyloxy)phényl]) Propionamide(2-[4-(trifluoromésyloxy)phényl]-N-[4-(trifluorométhyl)thiazol-2-yl]) Propionique acide(2-[4-(trifluoromésyloxy)phényl])
- Keyword (en)
- Carboxylic acid Affinity Antagonist Antiinflammatory agent Arylpropionic acid derivatives Human In vitro Allosteric inhibitor Interleukin 8 Leukocyte Macrophage Molecular model Modeling Structure activity relation CXCR1 chemokine receptor CXCR2 chemokine receptor Sulfonate Chemical synthesis
- Keyword (es)
- Acido carboxílico Afinidad Antagonista Antiinflamatorio Arilpropionico ácido derivado Hombre In vitro Inhibidor alostérico Interleuquina 8 Leucocito Macrófago Modelo molecular Modelización Relación estructura actividad Receptor quimioquina CXCR1 Receptor quimioquina CXCR2 Sulfonato Síntesis química
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 19018810
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm061469t 
https://dx.doi.org/10.1021/jm061469t
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