Spectroscopic studies of DNA binding modes of cation-substituted anthrapyrazoles derived from emodin
- Author
- TAN, Jia-Heng1 ; LU, Yu-Jing1 ; HUANG, Zhi-Shu1 ; GU, Lian-Quan1 ; WU, Jian-Yong2
[1] School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, China
[2] Department of Applied Biology and Chemical Technology and State Key Lab of Chinese Medicine and Molecular Pharmacology, The Hong Kong Polytechnic University, Hung Horn, Kowloon, Hong-Kong - Source
European journal of medicinal chemistry. 2007, Vol 42, Num 9, pp 1169-1175, 7 p ; ref : 36 ref
- CODEN
- EJMCA5
- ISSN
- 0223-5234
- Scientific domain
- Organic chemistry; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Amino side chain Anthrapyrazole DNA binding Emodin Spectroscopic analysis
- Keyword (fr)
- Agent intercalant Amine tertiaire Animal Anticancéreux Cellule tumorale Chaîne latérale Composé aromatique Composé tétracyclique Constante stabilité Cytotoxicité DNA Diamine Dérivé de l'anthrapyrazole Fixation biologique Foie Homme Hétérocycle azote In vitro Lignée cellulaire Mode liaison Mélanome B16 Quinone imine Relation structure activité Relation structure propriété Souris Spectrométrie CD Spectrométrie UV visible Spectrométrie fluorescence Spontané Tumeur de Lewis Anthra[1,9-cd]pyrazol-6-one dérivé Fixation DNA Lignée HEPG2 Mammalia Rodentia Vertebrata
- Keyword (en)
- Intercalating agent Tertiary amine Animal Antineoplastic agent Tumor cell Side chain Aromatic compound Tetracyclic compound Stability constant Cytotoxicity DNA Diamine Anthrapyrazole derivatives Biological fixation Liver Human Nitrogen heterocycle In vitro Cell line Binding mode B16-Melanoma Quinone imine Structure activity relation Property structure relationship Mouse Circular dichroism spectrometry Ultraviolet visible spectrometry Fluorescence spectrometry Spontaneous Lewis lung carcinoma Mammalia Rodentia Vertebrata
- Keyword (es)
- Agente intercalante Amina terciaria Animal Anticanceroso Célula tumoral Cadena lateral Compuesto aromático Compuesto tetracíclico Constante estabilidad Citotoxicidad DNA Diamina Anthrapyrazol derivado Fijación biológica Hígado Hombre Heterociclo nitrógeno In vitro Línea celular Modo de enlace Melanoma B16 Quinona imina Relación estructura actividad Relación estructura propiedad Ratón Espectrometría CD Espectrometría UV visible Espectrometría fluorescencia Espontáneo Tumor Lewis Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 19021923
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.ejmech.2007.02.002 
https://dx.doi.org/10.1016/j.ejmech.2007.02.002
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