Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage
- Author
- KUHN, Alexandre1 2 ; GOLDSTEIN, Darlene R1 ; HANNAN, Anthony J10 9 ; HAYDEN, Michael R6 ; LEAVITT, Blair R6 ; DUNNETT, Stephen B3 ; FERRANTE, Robert J11 ; ALBIN, Roger12 ; SHELBOURNE, Peggy13 ; DELORENZI, Mauro2 ; AUGOOD, Sarah J8 ; FAULL, Richard L. M14 ; HODGES, Angela3 4 ; OLSON, James M5 ; BATES, Gillian P7 ; JONES, Lesley3 ; LUTHI-CARTER, Ruth1 ; STRAND, Andrew D5 ; SENGSTAG, Thierry2 ; KOOPERBERG, Charles5 ; BECANOVIC, Kristina6 ; POULADI, Mahmoud A6 ; SATHASIVAM, Kirupa7 ; CHA, Jang-Ho J8
[1] Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
[2] National Center of Competence in Research (NCCR) Molecular Oncology, Swiss Institute of Experimental Cancer Research (ISREC) and Swiss Institute of Bioinformatics (SIB), 1066 Epalinges, Switzerland
[3] Departments of Psychological Medicine and Medical Genetics, Wales College of Medicine and School of Biosciences, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, United Kingdom
[4] Department of Psychological Medicine, Institute of Psychiatry, King's College London, London SE5 8AF, United Kingdom
[5] Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States
[6] Department of Medical Genetics, University of British Columbia, and Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Vancouver, BC, V5Z 4H4, Canada
[7] Department of Medical and Molecular Genetics, King's College London School of Medicine, London SE1 9RT, United Kingdom
[8] MassGeneral Institute of Neurodegenerative Disease (MIND), Massachusetts General Hospital, Charlestown, MA 02129, United States
[9] University Laboratory of Physiology, Oxford OX1 3PT, United Kingdom
[10] Howard Florey Institute, National Neuroscience Facility, University of Melbourne, VIC 3010, Australia
[11] Bedford Veterans Affairs Medical Center and Departments of Neurology, Pathology, Psychiatry, Boston University School of Medicine, Bedford, MA 07130, United States
[12] Geriatrics Research, Education, and Clinical Center, Ann Arbor Veterans Affairs Medical Center and Department of Neurology, University of Michigan, United States
[13] Division of Molecular Genetics, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 6NU, Scotland, United Kingdom
[14] Department of Anatomy with Radiology, University of Auckland, Private Bag 92019, Auckland, New Zealand - Source
Human molecular genetics (Print). 2007, Vol 16, Num 15, pp 1845-1861, 17 p ; ref : 57 ref
- Publisher
- Oxford University Press, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Chorée Huntington Encéphale pathologie Expression génique Génétique Homme Huntingtine Mutation Souris Extrapyramidal syndrome Maladie dégénérative Maladie héréditaire Mammalia Rodentia Système nerveux central pathologie Système nerveux pathologie Vertebrata
- Keyword (en)
- Huntington disease Cerebral disorder Gene expression Genetics Human Huntingtin Mutation Mouse Extrapyramidal syndrome Degenerative disease Genetic disease Mammalia Rodentia Central nervous system disease Nervous system diseases Vertebrata
- Keyword (es)
- Corea Huntington Encéfalo patología Expresión genética Genética Hombre Huntingtina Mutación Ratón Extrapiramidal síndrome Enfermedad degenerativa Enfermedad hereditaria Mammalia Rodentia Sistema nervosio central patología Sistema nervioso patología Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A04 Molecular and cellular biology
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17G Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
- Discipline
- Eukaryotes genetics. Biological and molecular evolution Molecular and cell biology Neurology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 19031190
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1093/hmg/ddm133 
https://dx.doi.org/10.1093/hmg/ddm133
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