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RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis

Author
SHUKIA, Vivek1 ; COUMOUL, Xavier1 ; WANG, Rui-Hong1 ; KIM, Hyun-Seok1 ; DENG, Chu-Xia1
[1] Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, US National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, United States
Source

Nature genetics. 2007, Vol 39, Num 9, pp 1145-1150, 6 p ; ref : 30 ref

CODEN
NGENEC
ISSN
1061-4036
Scientific domain
Genetics
Publisher
Nature Publishing Group, London
Publication country
United Kingdom
Document type
Article
Language
English
Keyword (fr)
Crâniosynostose Extracellular signal-regulated protein kinase Inhibition Modèle animal Phénotype Silence expression génique Souris Interférence ARN Crâne pathologie Dysostose Enzyme Mammalia Rodentia Système nerveux pathologie Système ostéoarticulaire pathologie Vertebrata
Keyword (en)
Craniosynostosis Extracellular signal-regulated protein kinase Inhibition Animal model Phenotype Gene silencing Mouse RNA interference Skull disease Dysostosis Enzyme Mammalia Rodentia Nervous system diseases Diseases of the osteoarticular system Vertebrata
Keyword (es)
Craneosinóstosis Extracellular signal-regulated protein kinase Inhibición Modelo animal Fenotipo Silencio expresión genética Ratón ARN interferencia Cráneo patología Disostosis Enzima Mammalia Rodentia Sistema nervioso patología Sistema osteoarticular patología Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B15 Diseases of the osteoarticular system / 002B15H Malformations and congenital and or hereditary diseases involving bones. Joint deformations

Discipline
Eukaryotes genetics. Biological and molecular evolution Osteoarticular pathology
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
19034201

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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