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Expression of the p210BCR-ABL oncoprotein drives centrosomal hypertrophy and clonal evolution in human U937 cells

Author
GIEHL, M1 ; FABARIUS, A1 ; FRANK, O1 ; ERBEN, P1 ; ZHENG, C1 ; HAFNER, M2 ; HOCHHAUS, A1 ; HEHLMANN, R1 ; SEIFARTH, W1
[1] III. Medizinische Universitätsklinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany
[2] Hochschule Mannheim, Institut für Molekulare Zellbiologie, Mannheim, Germany
Source

Leukemia. 2007, Vol 21, Num 9, pp 1971-1976, 6 p ; ref : 37 ref

CODEN
LEUKED
ISSN
0887-6924
Scientific domain
Medical oncology; Hematology
Publisher
Nature Publishing, London
Publication country
United Kingdom
Document type
Article
Language
English
Author keyword
aneuploidy centrosome hypertrophy chronic myeloid leukemia genetic instability imatinib p210BCR-ABL
Keyword (fr)
Aneuploïdie Anticancéreux Centrosome Clonalité Cytogénétique Gène onc cellulaire Gène onc Homme Hypertrophie Hématologie Imatinib Inhibiteur enzyme Lignée cellulaire établie Protein-tyrosine kinase Protooncogène Gène abl Inhibiteur de la tyrosine kinase Instabilité génétique Leucémie myéloïde chronique Lignée U937 Oncoprotéine Aberration chromosomique Enzyme Hémopathie maligne Myéloprolifératif syndrome Transferases
Keyword (en)
Aneuploidy Antineoplastic agent Centrosome Clonality Cytogenetics C-Onc gene Onc gene Human Hypertrophy Hematology Imatinib Enzyme inhibitor Established cell line Protein-tyrosine kinase Protooncogene Genetic instability Chronic myelocytic leukemia Oncoprotein Chromosomal aberration Enzyme Malignant hemopathy Myeloproliferative syndrome Transferases
Keyword (es)
Aneuploidía Anticanceroso Centrosoma Clonalidad Citogenética Gen onc celular Gen onc Hombre Hipertrofia Hematología Imatinib Inhibidor enzima Línea celular establecida Protein-tyrosine kinase Protooncogen Inestabilidad genética Leucemia mieloidea Aberración cromosómica Enzima Hemopatía maligna Mieloproliferativo síndrome Transferases
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B19 Hematologic and hematopoietic diseases / 002B19B Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B23 Medical genetics / 002B23B Chromosome aberrations

Discipline
Blood diseases Medical genetics
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
19034284

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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