Determination of the catechol-O-methyltransferase inhibitor tolcapone and three of its metabolites in animal and human plasma and urine by reversed-phase high-performance liquid chromatography with ultraviolet detection
- Author
- HEIZMANN, P1 ; SCHMITT, M1 ; LEUBE, J1 ; MARTIN, H1 ; SANER, A1
[1] Pharma Division, Nonclinical Development, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland - Source
Journal of chromatography. B, Biomedical sciences and applications. 1999, Vol 730, Num 2, pp 153-160 ; ref : 4 ref
- ISSN
- 1387-2273
- Scientific domain
- Biochemistry, molecular biology, biophysics; Medical laboratory techniques
- Publisher
- Elsevier Science, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Keyword (fr)
- Analyse quantitative Antiparkinsonien Catechol O-methyltransferase Chromatographie HPLC Chromatographie phase inverse Détecteur UV Homme Inhibiteur enzyme Liquide biologique Mesure simultanée Métabolite Plasma sanguin Tolcapone Urine Enzyme Methyltransferases Transferases
- Keyword (en)
- Quantitative analysis Antiparkinson agent Catechol O-methyltransferase HPLC chromatography Reversed phase chromatography Ultraviolet detector Human Enzyme inhibitor Biological fluid Simultaneous measurement Metabolite Blood plasma Tolcapone Urine Enzyme Methyltransferases Transferases
- Keyword (es)
- Análisis cuantitativo Antiparkinsoniano Catechol O-methyltransferase Cromatografía HPLC Cromatografía fase inversa Detector UV Hombre Inhibidor enzima Líquido biológico Medición simultánea Metabolito Plasma sanguíneo Tolcapona Orina Enzima Methyltransferases Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B06 Anticonvulsants. Antiepileptics. Antiparkinson agents
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 1910817
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/S0378-4347(99)00146-2 
https://dx.doi.org/10.1016/S0378-4347(99)00146-2
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