Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP
- Author
- PIROPG-GARCIA, Katarzyna A1 ; MEADOWS, Roger S1 ; KNOWLES, Lynette1 ; HEINEGARD, Dick2 ; THORNTON, David J1 ; KADLER, Karl E1 ; BOOT-HANDFORD, Raymond P1 ; BRIGGS, Michael D1
[1] Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, M13 9PT Manchester, United Kingdom
[2] Biomedical Centre, Lund University, BMC C12, 221 84 Lund, Sweden - Source
Human molecular genetics (Print). 2007, Vol 16, Num 17, pp 2072-2088, 17 p ; ref : 44 ref
- Publisher
- Oxford University Press, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Apoptose Dysplasie pseudoachondroplasique Génétique Modèle animal Multiplication cellulaire Mutation Mécanisme Souris Malformation Mammalia Rodentia Système ostéoarticulaire pathologie Vertebrata
- Keyword (en)
- Apoptosis Pseudoachondroplasia Genetics Animal model Cell proliferation Mutation Mechanism Mouse Malformation Mammalia Rodentia Diseases of the osteoarticular system Vertebrata
- Keyword (es)
- Apoptosis Displasia seudoacondroplásica Genética Modelo animal Multiplicación celular Mutación Mecanismo Ratón Malformación Mammalia Rodentia Sistema osteoarticular patología Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A04 Molecular and cellular biology / 002A04H Cell physiology / 002A04H05 Ageing, cell death
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B15 Diseases of the osteoarticular system / 002B15H Malformations and congenital and or hereditary diseases involving bones. Joint deformations
- Discipline
- Eukaryotes genetics. Biological and molecular evolution Molecular and cell biology Osteoarticular pathology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 19110255
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1093/hmg/ddm155 
https://dx.doi.org/10.1093/hmg/ddm155
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