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Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection : Results of a 48-week controlled study

MARKOWITZ, Martin1 ; NGUYEN, Bach-Yen2 ; GILDE, Lucinda R2 ; HONG WAN2 ; MILLER, Michael D2 ; WENNING, Larissa A2 ; TEPPLER, Hedy2 ; GOTUZZO, Eduardo3 ; MENDO, Fernando4 ; RATANASUWAN, Winai5 ; KOVACS, Colin6 ; PRADA, Guillermo7 ; MORALES-RAMIREZ, Javier O8 ; CRUMPACKER, Clyde S9 ; ISAACS, Robin D2
[1] Aaron Diamond AIDS Research Center, Rockefeller University, New York, NY, United States
[2] Merck Research Laboratories, West Point, PA, United States
[3] Hospital Nacionale Cayetano Heredia, Lima, Peru
[4] Hospital Nacionale Edgardo Rebagliati, Lima, Peru
[5] Siriraj Hospital, Bangkok, Thailand
[6] Canadian Immunodeficiency Research Collaborative, Toronto, Ontario, Canada
[7] Fundación Santafe de Bogota University Hospital, Bogotá, Colombia
[8] Clinical Research Puerto Rico, Inc, San Juan, Puerto Rico
[9] Beth Israel Deaconess Medical Center, Boston, MA, United States
Protocol 004 Part II Study Team

Journal of acquired immune deficiency syndromes (1999). 2007, Vol 46, Num 2, pp 125-133, 9 p ; ref : 27 ref

Scientific domain
Immunology, immunopathology, allergology; Virology
Lippincott Williams & Wilkins, Hagerstown, MD
Publication country
United States
Document type
Author keyword
HIV-1 MK-0518 antiretroviral therapy integrase inhibitor raltegravir
Keyword (fr)
Antirétroviral Antiviral Association médicamenteuse Chimiothérapie Microbiologie SIDA Traitement Virologie Virus HIV1 Immunodéficit Immunopathologie Infection Lentivirus Retroviridae Virose Virus immunodéficience humaine Virus
Keyword (en)
Antiretroviral agent Antiviral Drug combination Chemotherapy Microbiology AIDS Treatment Virology HIV-1 virus Immune deficiency Immunopathology Infection Lentivirus Retroviridae Viral disease Human immunodeficiency virus Virus
Keyword (es)
Antiretroviral Antiviral Asociación medicamentosa Quimioterapia Microbiología SIDA Tratamiento Virología HIV-1 virus Inmunodeficiencia Inmunopatología Infección Lentivirus Retroviridae Virosis Human immunodeficiency virus Virus
002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A05 Microbiology / 002A05C Virology / 002A05C10 Miscellaneous

002 Biological and medical sciences / 002B Medical sciences / 002B05 Infectious diseases / 002B05C Viral diseases / 002B05C02 Human viral diseases / 002B05C02D Viral diseases of the lymphoid tissue and the blood. Aids

002 Biological and medical sciences / 002B Medical sciences / 002B05 Infectious diseases / 002B05C Viral diseases / 002B05C02 Human viral diseases / 002B05C02J Miscellaneous

Infectious pathology Microbiology
INIST identifier

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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