Synthesis, DNA binding, and cytotoxicity studies of pyrrolo [2,1 -c][1,4 ]benzodiazepine -anthraquinone conjugates
- Author
- KAMAL, Ahmed1 ; RAMU, R1 ; TEKUMALLA, Venkatesh1 ; RAMESH KHANNA, G. B1 ; BARKUME, Madan S2 ; JUVEKAR, Aarti S2 ; ZINGDE, Surekha M2
[1] Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
[2] Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Khargar, Navi Mumbai 410 208, India - Source
Bioorganic & medicinal chemistry. 2007, Vol 15, Num 22, pp 6868-6875, 8 p ; ref : 22 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Anthraquinones Anticancer activity DNA binding Pyrrolobenzodiazepines
- Keyword (fr)
- Anticancéreux Cellule tumorale Composé aromatique Composé benzénique condensé Composé conjugué Composé tricyclique Cytotoxicité DNA Dérivé de l'anthraquinone Fixation biologique Hétérocycle azote angulaire In vitro Lactame Lignée cellulaire Longueur chaîne Quinone Relation structure activité Synthèse chimique Fixation DNA Pyrrolo[2,1-c][1,4]benzodiazépin-5-one dérivé Pyrrolobenzodiazépine
- Keyword (en)
- Antineoplastic agent Tumor cell Aromatic compound Condensed benzenic compound Conjugated compound Tricyclic compound Cytotoxicity DNA Anthraquinone derivatives Biological fixation Angular nitrogen heterocycle In vitro Lactam Cell line Chain length Quinone Structure activity relation Chemical synthesis
- Keyword (es)
- Anticanceroso Célula tumoral Compuesto aromático Compuesto bencénico condensado Compuesto conjugado Compuesto tricíclico Citotoxicidad DNA Antraquinona derivado Fijación biológica Heterociclo nitrógeno angular In vitro Lactamo Línea celular Longitud cadena Quinona Relación estructura actividad Síntesis química
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 19133329
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2007.08.026 
https://dx.doi.org/10.1016/j.bmc.2007.08.026
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