Synthesis, biological evaluation and molecular modeling studies of arylidene-thiazolidinediones with potential hypoglycemic and hypolipidemic activities
- Author
- DA COSTA LEITE, Lucia Fernanda C1 ; MOURAO, Rosa Helena Veras2 ; DE LIMA, Maria Do Carmo Alves2 ; LINS GALDINO, Suely2 ; ZALDINI HEMANDES, Marcelo3 ; ROCHA NEVES, Francisco De Assis4 ; VIDAL, Stéphanie5 ; BARBE, Jacques5 ; DA ROCHA PITTA, Ivan2
[1] Departamento de Química, Universidade Católica de Pernambuco, Brazil
[2] Departamento de Antibióticos, Universidade Fédéral de Pernambuco, CEP 50670-901 Recife, Pernambuco, Brazil
[3] Ciências Farmacêuticas, Universidade Fédéral de Pernambuco, CEP 50670-901 Recife, Pernambuco, Brazil
[4] Universidade de Brasília, CEP 70910-900 Brasília, DF, Brazil
[5] GERCTOP, UMR CNRS 6178, Université de la Méditerranée, Faculté de Pharmacie, 13385 Marseille, France - Source
European journal of medicinal chemistry. 2007, Vol 42, Num 10, pp 1263-1271, 9 p ; ref : 26 ref
- CODEN
- EJMCA5
- ISSN
- 0223-5234
- Scientific domain
- Organic chemistry; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Arylidene-thiazolidinediones Docking Hypoglycemic Hypolipidemic Molecular modeling
- Keyword (fr)
- Animal Dérivé de la thiazolidinedione Hypoglycémiant Hypolipémiant Modèle moléculaire Modélisation Relation structure activité Récepteur PPAR-γ Récepteur nucléaire Site fixation Souris Synthèse chimique Thiazolidine-2,4-dione(5-arylméthylène-3-[4-méthylbenzyl]) Mammalia Rodentia Vertebrata
- Keyword (en)
- Animal Thiazolidinedione derivatives Hypoglycemic agent Antilipemic agent Molecular model Modeling Structure activity relation PPAR-γ receptor Nuclear receptor Binding site Mouse Chemical synthesis Mammalia Rodentia Vertebrata
- Keyword (es)
- Animal Tiazolidinediona derivado Hipoglicemiante Hipolipemiante Modelo molecular Modelización Relación estructura actividad Receptor PPAR-γ Receptor nuclear Sitio fijación Ratón Síntesis química Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 19174941
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.ejmech.2007.02.015 
https://dx.doi.org/10.1016/j.ejmech.2007.02.015
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