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A novel strategy to assemble the β-diketo acid pharmacophore of HIV integrase inhibitors on purine nucleobase scaffolds

Author
UCHIL, Vinod1 ; SEO, Byung1 ; NAIR, Vasu1
[1] The Center for Drug Discovery and the Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602, United States
Source

Journal of organic chemistry. 2007, Vol 72, Num 22, pp 8577-8579, 3 p ; ref : 33 ref

CODEN
JOCEAH
ISSN
0022-3263
Scientific domain
Biochemistry, molecular biology, biophysics; Organic chemistry
Publisher
American Chemical Society, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Acide carboxylique Acylation Addition chimique Base nucléique Base purique Complexe de palladium Composé aromatique Condensation Claisen Dérivé de la purine Dérivé de la pyrimidine Ester Ether Hydrolyse Hétérocycle azote Inhibiteur enzyme Réaction catalytique Réaction croisée Réaction tandem Synthèse chimique Sélectivité Virus immunodéficience humaine Pharmacophore Lentivirus Retroviridae Virus
Keyword (en)
Carboxylic acid Acylation Addition reaction Nucleic base Purine base Palladium complex Aromatic compound Claisen condensation Purine derivatives Pyrimidine derivatives Ester Ether Hydrolysis Nitrogen heterocycle Enzyme inhibitor Catalytic reaction Cross reaction Tandem reaction Chemical synthesis Selectivity Human immunodeficiency virus Lentivirus Retroviridae Virus
Keyword (es)
Acido carboxílico Acilación Adición química Base nucleica Base púrica Paladio complejo Compuesto aromático Condensación Claisen Purina derivado Pirimidina derivado Ester Eter Hidrólisis Heterociclo nitrógeno Inhibidor enzima Reacción catalítica Reacción cruzada Reacción tándem Síntesis química Selectividad Human immunodeficiency virus Lentivirus Retroviridae Virus
Classification
Pascal
001 Exact sciences and technology / 001C Chemistry / 001C03 Organic chemistry / 001C03C Preparations and properties / 001C03C06 Heterocyclic compounds / 001C03C06C Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings

Discipline
Organic chemistry
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
19193841

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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