First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine) : Conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus
- Author
- PERRONE, Plinio1 ; DAVERIO, Felice1 ; MCGUIGAN, Christopher1 ; VALENTE, Rocco1 ; RAJYAGURU, Sonal2 ; MARTIN, Joseph A2 ; LEVEQUE, Vincent2 ; LE POGAM, Sophie2 ; NAJERA, Isabel2 ; KLUMPP, Klaus2 ; SMITH, David B2
[1] Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, United Kingdom
[2] Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, California 94304, United States - Source
Journal of medicinal chemistry (Print). 2007, Vol 50, Num 22, pp 5463-5470, 8 p ; ref : 24 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Antiviral Azide Cytotoxicité Dérivé du naphtalène In vitro Phosphoramidate organique Phosphore Composé organique Promédicament Purine nucléotide Synthèse chimique Virus hépatite C Adénosine(4p-azido)-5p-phosphoramidate(N-[1-éthoxycarbonyléthyl]-O-[1-naphtyl]) Alanine dérivé Flaviviridae Hepacivirus Virus
- Keyword (en)
- Biological activity Antiviral Organic azide Cytotoxicity Naphthalene derivatives In vitro Organic amidophosphate Phosphorus Organic compounds Prodrug Purine nucleotide Chemical synthesis Hepatitis C virus Flaviviridae Hepacivirus Virus
- Keyword (es)
- Actividad biológica Antiviral Azida orgánica Citotoxicidad Naftaleno derivado In vitro Fosforamidato orgánico Fósforo Compuesto orgánico Promedicamento Purina nucleótido Síntesis química Hepatitis C virus Flaviviridae Hepacivirus Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 19195245
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm070362i 
https://dx.doi.org/10.1021/jm070362i
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