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Cisplatin depletes TREX2 and causes robertsonian translocations as seen in TREX2 knockout cells

Author
CHEN, Ming-Jiu1 ; DUMITRACHE, Lavinia C1 ; WANGSA, Danny2 ; MA, Sheng-Mei1 ; PADILLA-NASH, Hesed2 ; RIED, Thomas2 ; HASTY, Paul1
[1] Department of Molecular Medicine/Institute of Biotechnology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States
[2] Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States
Source

Cancer research (Baltimore). 2007, Vol 67, Num 19, pp 9077-9083, 7 p ; ref : 42 ref

CODEN
CNREA8
ISSN
0008-5472
Scientific domain
Medical oncology; Pharmacology drugs
Publisher
American Association for Cancer Research, Philadelphia, PA
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Anticancéreux Ciblage Cisplatine Cytogénétique Gène In vitro Mutation Translocation chromosomique Aberration chromosomique Agent alkylant Chromosome anormal Génétique Platine II Complexe
Keyword (en)
Antineoplastic agent Targeting Cisplatin Cytogenetics Gene In vitro Mutation Chromosome translocation Chromosomal aberration Alkylating agent Abnormal chromosome Genetics Platinum II Complexes
Keyword (es)
Anticanceroso Blancado Cisplatino Citogenética Gen In vitro Mutación Translocación cromosómica Aberración cromosómica Agente alquilante Cromosoma anormal Genética Platino II Complejo
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B23 Medical genetics / 002B23B Chromosome aberrations

Discipline
Medical genetics Pharmacological treatments Tumours
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
19203497

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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