A synthetic uracil derivative with antitumor activity through decreasing cyclin D1 and Cdk1, and increasing p21 and p27 in MCF-7 cells
- Author
- MARCHAL, Juan A1 ; NUNEZ, Maria C2 ; CAMPOS, Joaquin M2 ; SUAREZ, Inés3 ; DIAZ-GAVILAN, Monica2 ; GOMEZ-VIDAL, José A2 ; BOULAIZ, Houria1 ; RODRIGUEZ-SERRANO, Fernando1 ; GALLO, Miguel A2 ; ESPINOSA, Antonio2 ; ARANEGA, Antonia3
[1] Departamento de Ciencias de la Salud, Facultad de Ciencias Experimentales y de la Salud, Paraje de las Lagunillas s/n, 23071 Jaen, Spain
[2] Departamento de Química Farmacéutica y Orgànica, Facultad de Farmacia, Universidad de Granada, c/Campus de Cartuja s/n, 18071 Granada, Spain
[3] Departamento de Anatomía y Embriología Humana, Facultad de Medicina, Avenida de Madrid s/n, 18071 Granada, Spain - Source
Breast cancer research and treatment. 2007, Vol 105, Num 3, pp 237-246, 10 p ; ref : 46 ref
- CODEN
- BCTRD6
- ISSN
- 0167-6806
- Scientific domain
- Medical oncology; Obstetrics, gynecology, andrology; Pharmacology drugs
- Publisher
- Springer, Dordrecht
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Breast cancer Cyclin Dl Cdk1 MCF-7 p21 p27·Uracil derivative
- Keyword (fr)
- Activité biologique Anticancéreux Cycle cellulaire Cycline D1 Gène CDKN1A Gène KIP1 Gène onc cellulaire Gène suppresseur tumeur In vitro Lignée cellulaire établie Produit synthétique Protooncogène Uracile Cancer du sein Lignée MCF7 Cancer Pathologie de la glande mammaire Tumeur maligne
- Keyword (en)
- Biological activity Antineoplastic agent Cell cycle Cyclin D1 CDKN1A Gene KIP1 Gene C-Onc gene Tumor suppressor gene In vitro Established cell line Synthetic product Protooncogene Uracil Breast cancer Cancer Mammary gland diseases Malignant tumor
- Keyword (es)
- Actividad biológica Anticanceroso Ciclo celular Ciclina D1 Gen CDKN1A Gen KIP1 Gen onc celular Gen supresor tumor In vitro Línea celular establecida Producto sintético Protooncogen Uracilo Cáncer de pecho Cáncer Glándula mamaria patología Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B20 Gynecology. Andrology. Obstetrics / 002B20E Mammary gland diseases / 002B20E02 Tumors
- Discipline
- Gynecology. Andrology. Obstetrics
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 19225129
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1007/s10549-006-9450-2 
https://dx.doi.org/10.1007/s10549-006-9450-2
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