Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD
- Author
- GROOTENDORST, Diana C1 ; GAUW, Stefanie A1 ; VERHOOSEL, Renate M1 ; STERK, Peter J1 ; HOSPERS, Jeannette J2 ; BREDENBRÖKER, Dirk2 ; BETHKE, Thomas D2 ; HIEMSTRA, Pieter S1 ; RABE, Klaus F1
[1] Department of Pulmonology, Leiden University Medical Center, Leiden, Netherlands
[2] ALTANA Pharma AG, Konstanz, Germany - Source
Thorax. 2007, Vol 62, Num 12, pp 1081-1087, 7 p ; ref : 39 ref
- CODEN
- THORA7
- ISSN
- 0040-6376
- Scientific domain
- Anesthesia, intensive care; Cardiology, blood circulation, phlebology; Pneumology
- Publisher
- BMJ, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antiasthmatique Appareil circulatoire pathologie Appareil respiratoire pathologie Bronchopneumopathie obstructive Chronique Eosinophile Expectoration Granulocyte Homme Malade Neutrophile Nombre Roflumilast Réduction Bronchopneumopathie chronique obstructive Inhibiteur de la phosphodiesterase Inhibiteur de la phosphodiestérase 4 3',5'-Cyclic-nucleotide phosphodiesterase Bronche pathologie Enzyme Esterases Hydrolases Inhibiteur enzyme Phosphoric diester hydrolases Poumon pathologie
- Keyword (en)
- Antiasthma agent Cardiovascular disease Respiratory disease Obstructive pulmonary disease Chronic Eosinophil Sputum Granulocyte Human Patient Neutrophil Number Roflumilast Reduction Chronic obstructive pulmonary disease Phosphodiesterase inhibitor 3',5'-Cyclic-nucleotide phosphodiesterase Bronchus disease Enzyme Esterases Hydrolases Enzyme inhibitor Phosphoric diester hydrolases Lung disease
- Keyword (es)
- Agente antiasma Aparato circulatorio patología Aparato respiratorio patología Broncopneumopatía obstructiva Crónico Eosinófilo Expectoración Granulocito Hombre Enfermo Neutrófilo Número Roflumilast Reducción Enfermedad pulmonar obstructiva crónica Inhibidor phosphodiesterase 3',5'-Cyclic-nucleotide phosphodiesterase Bronquio patología Enzima Esterases Hydrolases Inhibidor enzima Phosphoric diester hydrolases Pulmón patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B11 Pneumology / 002B11B Chronic obstructive pulmonary disease, asthma
- Discipline
- Pulmonology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 19282342
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Access to the document
Install on your browser
DOI
10.1136/thx.2006.075937 
https://dx.doi.org/10.1136/thx.2006.075937
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:23:\"10.1136\/thx.2006.075937\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:109:\"Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD\";s:9:\"\u0000*\u0000jtitle\";s:6:\"Thorax\";s:9:\"\u0000*\u0000stitle\";s:6:\"Thorax\";s:7:\"\u0000*\u0000date\";s:4:\"2007\";s:9:\"\u0000*\u0000volume\";s:2:\"62\";s:8:\"\u0000*\u0000issue\";s:2:\"12\";s:8:\"\u0000*\u0000spage\";s:4:\"1081\";s:8:\"\u0000*\u0000epage\";s:4:\"1087\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0040-6376\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:12:\"GROOTENDORST\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Diana C\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:8:{i:0;s:16:\"GAUW, Stefanie A\";i:1;s:19:\"VERHOOSEL, Renate M\";i:2;s:14:\"STERK, Peter J\";i:3;s:20:\"HOSPERS, Jeannette J\";i:4;s:19:\"BREDENBR\u00d6KER, Dirk\";i:5;s:16:\"BETHKE, Thomas D\";i:6;s:18:\"HIEMSTRA, Pieter S\";i:7;s:13:\"RABE, Klaus F\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"THORA7\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:109:\"Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD\";s:8:\"\u0000*\u0000place\";s:6:\"London\";s:6:\"\u0000*\u0000pub\";s:3:\"BMJ\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"7\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:23:\"10.1136\/thx.2006.075937\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:109:\"Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD\";s:9:\"\u0000*\u0000jtitle\";s:6:\"Thorax\";s:9:\"\u0000*\u0000stitle\";s:6:\"Thorax\";s:7:\"\u0000*\u0000date\";s:4:\"2007\";s:9:\"\u0000*\u0000volume\";s:2:\"62\";s:8:\"\u0000*\u0000issue\";s:2:\"12\";s:8:\"\u0000*\u0000spage\";s:4:\"1081\";s:8:\"\u0000*\u0000epage\";s:4:\"1087\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0040-6376\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:12:\"GROOTENDORST\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Diana C\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:8:{i:0;s:16:\"GAUW, Stefanie A\";i:1;s:19:\"VERHOOSEL, Renate M\";i:2;s:14:\"STERK, Peter J\";i:3;s:20:\"HOSPERS, Jeannette J\";i:4;s:19:\"BREDENBR\u00d6KER, Dirk\";i:5;s:16:\"BETHKE, Thomas D\";i:6;s:18:\"HIEMSTRA, Pieter S\";i:7;s:13:\"RABE, Klaus F\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"THORA7\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:109:\"Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD\";s:8:\"\u0000*\u0000place\";s:6:\"London\";s:6:\"\u0000*\u0000pub\";s:3:\"BMJ\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"7\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:23:\"10.1136\/thx.2006.075937\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Unpaywall access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:23:\"10.1136\/thx.2006.075937\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:109:\"Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD\";s:9:\"\u0000*\u0000jtitle\";s:6:\"Thorax\";s:9:\"\u0000*\u0000stitle\";s:6:\"Thorax\";s:7:\"\u0000*\u0000date\";s:4:\"2007\";s:9:\"\u0000*\u0000volume\";s:2:\"62\";s:8:\"\u0000*\u0000issue\";s:2:\"12\";s:8:\"\u0000*\u0000spage\";s:4:\"1081\";s:8:\"\u0000*\u0000epage\";s:4:\"1087\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0040-6376\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:12:\"GROOTENDORST\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Diana C\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:8:{i:0;s:16:\"GAUW, Stefanie A\";i:1;s:19:\"VERHOOSEL, Renate M\";i:2;s:14:\"STERK, Peter J\";i:3;s:20:\"HOSPERS, Jeannette J\";i:4;s:19:\"BREDENBR\u00d6KER, Dirk\";i:5;s:16:\"BETHKE, Thomas D\";i:6;s:18:\"HIEMSTRA, Pieter S\";i:7;s:13:\"RABE, Klaus F\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"THORA7\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:109:\"Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD\";s:8:\"\u0000*\u0000place\";s:6:\"London\";s:6:\"\u0000*\u0000pub\";s:3:\"BMJ\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"7\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:11:\"BaseOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:23:\"10.1136\/thx.2006.075937\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:109:\"Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD\";s:9:\"\u0000*\u0000jtitle\";s:6:\"Thorax\";s:9:\"\u0000*\u0000stitle\";s:6:\"Thorax\";s:7:\"\u0000*\u0000date\";s:4:\"2007\";s:9:\"\u0000*\u0000volume\";s:2:\"62\";s:8:\"\u0000*\u0000issue\";s:2:\"12\";s:8:\"\u0000*\u0000spage\";s:4:\"1081\";s:8:\"\u0000*\u0000epage\";s:4:\"1087\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0040-6376\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:12:\"GROOTENDORST\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Diana C\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:8:{i:0;s:16:\"GAUW, Stefanie A\";i:1;s:19:\"VERHOOSEL, Renate M\";i:2;s:14:\"STERK, Peter J\";i:3;s:20:\"HOSPERS, Jeannette J\";i:4;s:19:\"BREDENBR\u00d6KER, Dirk\";i:5;s:16:\"BETHKE, Thomas D\";i:6;s:18:\"HIEMSTRA, Pieter S\";i:7;s:13:\"RABE, Klaus F\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"THORA7\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:109:\"Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD\";s:8:\"\u0000*\u0000place\";s:6:\"London\";s:6:\"\u0000*\u0000pub\";s:3:\"BMJ\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"7\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Base Search access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:23:\"10.1136\/thx.2006.075937\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:109:\"Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD\";s:9:\"\u0000*\u0000jtitle\";s:6:\"Thorax\";s:9:\"\u0000*\u0000stitle\";s:6:\"Thorax\";s:7:\"\u0000*\u0000date\";s:4:\"2007\";s:9:\"\u0000*\u0000volume\";s:2:\"62\";s:8:\"\u0000*\u0000issue\";s:2:\"12\";s:8:\"\u0000*\u0000spage\";s:4:\"1081\";s:8:\"\u0000*\u0000epage\";s:4:\"1087\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0040-6376\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:12:\"GROOTENDORST\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Diana C\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:8:{i:0;s:16:\"GAUW, Stefanie A\";i:1;s:19:\"VERHOOSEL, Renate M\";i:2;s:14:\"STERK, Peter J\";i:3;s:20:\"HOSPERS, Jeannette J\";i:4;s:19:\"BREDENBR\u00d6KER, Dirk\";i:5;s:16:\"BETHKE, Thomas D\";i:6;s:18:\"HIEMSTRA, Pieter S\";i:7;s:13:\"RABE, Klaus F\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"THORA7\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:109:\"Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD\";s:8:\"\u0000*\u0000place\";s:6:\"London\";s:6:\"\u0000*\u0000pub\";s:3:\"BMJ\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"7\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
