EXP3174, the AII antagonist human metabolite of Losartan, but not Losartan nor the angiotensin-converting enzyme inhibitor captopril, prevents the development of lethal ischemic ventricular arrhythmias in a canine model of recent myocardial infarction
- Author
- LYNCH, J. J1 ; STUMP, G. L1 ; WALLACE, A. A1 ; PAINTER, C. A1 ; THOMAS, J. M2 ; KUSMA, S. E2 ; GOULD, R. J1 ; GROSSMAN, W3
[1] Department of Pharmacology, Merck Research Laboratories, West Point, Pennsylvania, United States
[2] Department of Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania, United States
[3] Department of Clinical Cardiovascular Research, Merck Research Laboratories, West Point, Pennsylvania, United States - Source
Journal of the American College of Cardiology. 1999, Vol 34, Num 3, pp 876-884 ; ref : 48 ref
- CODEN
- JACCDI
- ISSN
- 0735-1097
- Scientific domain
- Cardiology, blood circulation, phlebology
- Publisher
- Elsevier Science, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Antagoniste angiotensine Antiarythmique Captopril Chien Chimiothérapie Etude longitudinale Indice gravité Infarctus Inhibiteur enzyme Losartan Myocarde Métabolite Peptidyl-dipeptidase A Pronostic Survie Traitement Trouble rythme cardiaque Vasodilatateur Ventricule cardiaque Angiotensin converting enzyme EXP3174 Appareil circulatoire pathologie Cardiopathie coronaire Cardiopathie Carnivora Enzyme Fissipedia Hydrolases Mammalia Myocarde pathologie Peptidases Peptidyl-dipeptidases Vertebrata
- Keyword (en)
- Animal Angiotensin antagonist Antiarrhythmic agent Captopril Dog Chemotherapy Follow up study Severity score Infarct Enzyme inhibitor Losartan Myocardium Metabolite Peptidyl-dipeptidase A Prognosis Survival Treatment Arrhythmia Vasodilator agent Heart ventricle Cardiovascular disease Coronary heart disease Heart disease Carnivora Enzyme Fissipedia Hydrolases Mammalia Myocardial disease Peptidases Peptidyl-dipeptidases Vertebrata
- Keyword (es)
- Animal Antagonista angiotensina Antiarrítmico Captopril Perro Quimioterapia Estudio longitudinal Indicio gravedad Infarto Inhibidor enzima Losartán Miocardio Metabolito Peptidyl-dipeptidase A Pronóstico Sobrevivencia Tratamiento Arritmia Vasodilatador Ventrículo cardíaco Aparato circulatorio patología Cardiopatía coronaria Cardiopatía Carnivora Enzima Fissipedia Hydrolases Mammalia Miocardio patología Peptidases Peptidyl-dipeptidases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02F Cardiovascular system / 002B02F02 Antiarythmic agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 1932409
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/S0735-1097(99)00253-3 
https://dx.doi.org/10.1016/S0735-1097(99)00253-3
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