Three-dimensional quantitative structure-activity relationships and activity predictions of human TRPV1 channel antagonists : Comparative molecular field analysis and comparative molecular similarity index analysis of cinnamides
- Author
- VISWANADHAN, Vellarkad N1 ; YAXIONG SUN1 ; NORMAN, Mark H2
[1] Molecular Structure and Design, Chemistry Research and Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1789, United States
[2] Medicinal Chemistry, Chemistry Research and Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1789, United States - Source
Journal of medicinal chemistry (Print). 2007, Vol 50, Num 23, pp 5608-5619, 12 p ; ref : 37 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antagoniste Carboxamide Dérivé de la pyrimidine Homme In vitro Modèle 3 dimensions Modèle moléculaire Modélisation Méthode CoMFA Méthode CoMSIA Prédiction Relation structure activité Récepteur vanilloïde VR1 1,4-Benzodioxane dérivé Canal ionique TRP Cinnamamide dérivé QSAR Récepteur vanilloïde TRPV1
- Keyword (en)
- Antagonist Carboxamide Pyrimidine derivatives Human In vitro Three dimensional model Molecular model Modeling Comparative molecular field analysis method Comparative molecular similarity indices analysis method Prediction Structure activity relation VR1 vanilloid receptor TRP ion channel TRPV1 vanilloid receptor
- Keyword (es)
- Antagonista Carboxamida Pirimidina derivado Hombre In vitro Modelo 3 dimensiones Modelo molecular Modelización Método CoMFA Método CoMSIA Predicción Relación estructura actividad Receptor vaniloide VR1
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 19376025
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm070261k 
https://dx.doi.org/10.1021/jm070261k
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