Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
- Author
- MILNE, Jill C1 ; LAMBERT, Philip D1 ; BEMIS, Jean E1 ; ROGER XIE1 ; DISCH, Jeremy S1 ; PUI YEE NG1 ; NUNES, Joseph J1 ; LYNCH, Amy V1 ; HONGYING YANG1 ; GALONEK, Heidi1 ; ISRAELIAN, Kristine1 ; CHOY, Wendy1 ; SCHENK, Simon2 ; IFFLAND, Andre1 ; LAVU, Siva3 ; MEDVEDIK, Oliver3 ; SINCLAIR, David A4 ; OLEFSKY, Jerrold M2 ; JIROUSEK, Michael R3 ; ELLIOTT, Peter J3 ; WESTPHAL, Christoph H3 ; CARNEY, David P1 ; SMITH, Jesse J1 ; GAGNE, David J1 ; LEI JIN1 ; BOSS, Olivier1 ; PERNI, Robert B1 ; VU, Chi B1
[1] Sirtris Pharmaceuticals Inc., 790 Memorial Drive, Cambridge, Massachusetts 02139, United States
[2] Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States
[3] Sirtris Pharmaceuticals Inc., 790 Memorial Drive, Cambridge, Massachusetts 02139, United States
[4] Department of Pathology, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States - Source
Nature (London). 2007, Vol 450, Num 7170, pp 712-716, 5 p ; ref : 28 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Antioxydant Criblage haut débit Diabète de type 2 In vitro In vivo Pharmacothérapie Polyphénol Rat Resvératrol Souris Traitement Gène SIRT1 Dérivé du stilbène Endocrinopathie Maladie métabolique Mammalia Phénols Rodentia Vertebrata
- Keyword (en)
- Animal Antioxidant High throughput screening Type 2 diabetes In vitro In vivo Pharmacotherapy Polyphenol Rat Resveratrol Mouse Treatment SIRT1 Stilbene derivatives Endocrinopathy Metabolic diseases Mammalia Phenols Rodentia Vertebrata
- Keyword (es)
- Animal Antioxidante Cribado alta productividad Diabetes de tipo 2 In vitro In vivo Farmacoterapia Polifenol Rata Resveratrol Ratón Tratamiento Estilbeno derivado Endocrinopatía Metabolismo patología Mammalia Fenoles Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B21 Endocrinopathies / 002B21E Endocrine pancreas. Apud cells (diseases) / 002B21E01 Diabetes. Impaired glucose tolerance / 002B21E01A Etiopathogenesis. Screening. Investigations. Target tissue resistance
- Discipline
- Endocrinopathies
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 19690634
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature06261 
https://dx.doi.org/10.1038/nature06261
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