Distribution of a 20-mer phosphorothioate oligonucleotide, CGP69846A (ISIS 5132), into airway leukocytes and epithelial cells following intratracheal delivery to Brown-Norway rats
- Author
- DANAHAY, H1 ; GIDDINGS, J1 ; CHRISTIAN, R. A1 ; MOSER, H. E1 ; PHILLIPS, J. A1
[1] Novartis Horsham Research Centre, Horsham, West Sussex RH12 5AB, United Kingdom - Source
Pharmaceutical research. 1999, Vol 16, Num 10, pp 1542-1549 ; ref : 23 ref
- CODEN
- PHREEB
- ISSN
- 0724-8741
- Scientific domain
- Pharmacology drugs
- Publisher
- Springer, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Appareil respiratoire Cellule épithéliale Distribution Inflammation Leucocyte Libération Métabolisme Oligonucléotide antisens Pharmacocinétique Poumon Principe actif Rat Technologie pharmaceutique Thiophosphate organique Thérapie génique Voie intratrachéale Mammalia Rodentia Vertebrata
- Keyword (en)
- Animal Respiratory system Epithelial cell Distribution Inflammation Leukocyte Release Metabolism Antisense oligonucleotide Pharmacokinetics Lung Active ingredient Rat Pharmaceutical technology Organic thiophosphate Gene therapy Intratracheal administration Mammalia Rodentia Vertebrata
- Keyword (es)
- Animal Aparato respiratorio Célula epitelial Distribución Inflamación Leucocito Liberación Metabolismo Oligonucleótido antisentido Farmacocinética Pulmón Principio activo Rata Tecnología farmacéutica Tiofosfato orgánico Terapia génica Vía intratraqueal Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A31 Biotechnology / 002A31D Industrial applications and implications. Economical aspects / 002A31D01 Health. Pharmaceutical industry / 002A31D01D Gene therapy
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A03 Pharmaceutical technology. Pharmaceutical industry
- Discipline
- Biotechnology General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 1989791
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1023/A:1015048419558 
https://dx.doi.org/10.1023/A:1015048419558
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