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2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

Author
GASPARINI, F1 ; LINGENHÖHL, K1 ; VARNEY, M. A2 ; JOHNSON, E. C2 ; HESS, S. D2 ; RAO, S. P2 ; SACAAN, A. I2 ; SANTORI, E. M2 ; VELICELEBI, G2 ; KUHN, R1 ; STOEHR, N1 ; FLOR, P. J1 ; HEINRICH, M1 ; VRANESIC, I1 ; BIOLLAZ, M1 ; ALLGEIER, H1 ; HECKENDORN, R1 ; URWYLER, S1
[1] Novartis Pharma AG, Therapeutic Area Nervous System, 4002 Basle, Switzerland
[2] SIBIA Neurosciences Incorporated, 505 Coast Boulevard South, Suite 300, La Jolla, CA 92037-4641, United States
Issue title
Metabotropic Glutamate Receptors
Author (monograph)
COLLINGRIDGE, Graham L (Editor)1 ; LODGE, David (Editor)2 3
[1] Department of Anatomy, School of Medical Sciences, MRC Centre for Synaptic Plasticity, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
[2] Eli Lilly & Co. Ltd, Lilly Corporate Centre, Indianapolis, IN, United States
[3] Lilly Research Centre, Eli Lilly & Co. Ltd, Erl Wood Manor, Windlesham, Surrey GU20 6PH, United Kingdom
Source

Neuropharmacology. 1999, Vol 38, Num 10, pp 1493-1503 ; ref : 1 p.1/4

CODEN
NEPHBW
ISSN
0028-3908
Scientific domain
Neurology; Pharmacology drugs; Psychology, psychopathology, psychiatry
Publisher
Elsevier, Oxford
Publication country
United Kingdom
Document type
Article
Language
English
Keyword (fr)
AMP cyclique Activité biologique Animal Antagoniste Electrophysiologie Encéphale Expression génique GTP Grenouille Homme In vitro In vivo Inositophospholipide Lignée cellulaire établie Pyridine dérivé Rat Récepteur glutamate Récepteur ionotropique Récepteur métabotropique Système nerveux central Pyridine(2-méthyl-6-phényléthynyl) Sous-unité mGluR5 Amphibia Mammalia Rodentia Salientia Vertebrata
Keyword (en)
Cyclic AMP Biological activity Animal Antagonist Electrophysiology Brain (vertebrata) Gene expression GTP Frog Human In vitro In vivo Phosphoinositide Established cell line Pyridine derivatives Rat Glutamate receptor Ionotropic receptor Metabotropic receptor Central nervous system Amphibia Mammalia Rodentia Salientia Vertebrata
Keyword (es)
AMP cíclico Actividad biológica Animal Antagonista Electrofisiología Encéfalo Expresión genética GTP Rana Hombre In vitro In vivo Inositofosfolípido Línea celular establecida Piridina derivado Rata Receptor glutámato Receptor ionotropico Receptor metabotropico Sistema nervioso central Amphibia Mammalia Rodentia Salientia Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A04 Molecular and cellular biology / 002A04F Cell structures and functions / 002A04F03 Cell receptors / 002A04F03C Aminoacid receptors (glycine, glutamate, gaba)

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09E Glutamatergic system (aspartate and other excitatory aminoacids)

Discipline
Molecular and cell biology Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
1990678

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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