Small-molecule XIAP antagonist restores caspase-9-mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells
- Author
- CILLESSEN, Saskia A. G. M1 ; REED, John C2 ; OSSENKOPPELE, Gert J4 ; METIER, Chris J. L. M1 ; OUDEJANS, Joost J1 ; WELSH, Kate2 ; PINILLA, Clemencia3 ; HOUGHTEN, Richard3 ; HOOIJBERG, Erik1 ; DEURHOF, José1 ; CASTRICUM, Kitty C. M1 ; KORTMAN, Pim1 ; HESS, Corine J4
[1] Department of Clinical Pathology, VU University Medical Center, Amsterdam, Netherlands
[2] Burnham institute for Medical Research, La Jolla, CA, Netherlands
[3] Torrey Pines Institute for Molecular Studies, San Diego, CA, Netherlands
[4] Department of Hematology, VU University Medical Center, Amsterdam, Netherlands - Source
Blood. 2008, Vol 111, Num 1, pp 369-375, 7 p ; ref : 40 ref
- ISSN
- 0006-4971
- Scientific domain
- Medical oncology; Hematology
- Publisher
- The Americain Society of Hematology, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antagoniste Anticancéreux Apoptose Caspase Chimiosensibilité Chimiothérapie Etoposide Homme In vitro Lymphome diffus à grandes cellules B Mort cellulaire Protéine inhibitrice de l'apoptose Résistance traitement Caspase 9 Hémopathie lymphoïde B Protéine XIAP Antimitotique Cancer DNA topoisomerase (ATP-hydrolysing) Dérivé de la podophyllotoxine Enzyme Hydrolases Hémopathie maligne Inhibiteur enzyme Isomerases Peptidases Syndrome lymphoprolifératif Traitement
- Keyword (en)
- Antagonist Antineoplastic agent Apoptosis Caspase Chemosensitivity Chemotherapy Etoposide Human In vitro Diffuse large B cell lymphoma Cell death Apoptosis inhibitory protein Treatment resistance B cell neoplasm X linked inhibitor of apoptosis protein Antimitotic Cancer DNA topoisomerase (ATP-hydrolysing) Podophyllotoxin derivatives Enzyme Hydrolases Malignant hemopathy Enzyme inhibitor Isomerases Peptidases Lymphoproliferative syndrome Treatment
- Keyword (es)
- Antagonista Anticanceroso Apoptosis Caspase Quimiosensibilidad Quimioterapia Etopósido Hombre In vitro Linfoma difuso de grandes células B Muerte celular Proteína inhibidora de la apoptosis Resistencia tratamiento Proteína XIAP Antimitótico Cáncer DNA topoisomerase (ATP-hydrolysing) Podofilotoxina derivado Enzima Hydrolases Hemopatía maligna Inhibidor enzima Isomerases Peptidases Linfoproliferativo síndrome Tratamiento
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 19953499
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1182/blood-2007-04-085480 
https://dx.doi.org/10.1182/blood-2007-04-085480
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