Small, Potent, and Selective Diaryl Phosphonate Inhibitors for Urokinase-Type Plasminogen Activator with In Vivo Antimetastatic Properties
- Author
- JOOSSENS, Jurgen1 ; ALI, Omar M1 ; HAEMERS, Achiel1 ; AUGUSTYNS, Koen1 ; EL-SAYED, Ibrahim1 ; SURPATEANU, Georgiana1 ; VAN DER VEKEN, Pieter1 ; LAMBEIR, Anne-Marie2 ; SETYONO-HAN, Buddy3 ; FOEKENS, John A3 ; SCHNEIDER, Anneliese4 ; SCHMALIX, Wolfgang4
[1] Laboratory of Medicinal Chemistry, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
[2] Laboratory of Medical Biochemistry, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
[3] Erasmus MC, Josephine Nefkens Institute, Department of Medical Oncology, Dr. Molewaterplein 50, 3015 GE Rotterdam, Netherlands
[4] Wilex AG, Grillparzestr. 10, 81675 Munich, Germany - Source
Journal of medicinal chemistry (Print). 2007, Vol 50, Num 26, pp 6638-6646, 9 p ; ref : 42 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Aminoacide Animal Anticancéreux Antimétastatique Carbamate organique Cellule tumorale Composé non peptide Glande mammaire Guanidines In vivo Inhibiteur enzyme Modèle moléculaire Modélisation Phosphonate organique Phosphore Composé organique Souris Synthèse chimique Sélectivité Voie intrapéritonéale u-Plasminogen activator Enzyme Hydrolases Mammalia Peptidases Rodentia Serine endopeptidases Vertebrata
- Keyword (en)
- Biological activity Aminoacid Animal Antineoplastic agent Antimetastatic agent Organic carbamate Tumor cell Non peptide compound Mammary gland Guanidines In vivo Enzyme inhibitor Molecular model Modeling Organic phosphonate Phosphorus Organic compounds Mouse Chemical synthesis Selectivity Intraperitoneal administration u-Plasminogen activator Enzyme Hydrolases Mammalia Peptidases Rodentia Serine endopeptidases Vertebrata
- Keyword (es)
- Actividad biológica Aminoácido Animal Anticanceroso Antimetastásico Carbamato orgánico Célula tumoral Compuesto no péptido Glándula mamaria Guanidinas In vivo Inhibidor enzima Modelo molecular Modelización Fosfonato orgánico Fósforo Compuesto orgánico Ratón Síntesis química Selectividad Vía intraperitoneal u-Plasminogen activator Enzima Hydrolases Mammalia Peptidases Rodentia Serine endopeptidases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 19973108
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm700962j 
https://dx.doi.org/10.1021/jm700962j
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