Amino acid derivatives as histone deacetylase inhibitors
- Author
- HUBBS, Jed L1 ; HUA ZHOU1 ; KRAL, Astrid M2 ; FLEMING, Judith C2 ; DAHLBERG, William K3 ; HUGHES, Bethany L3 ; MIDDLETON, Richard E3 ; SZEWCZAK, Alexander A3 ; SECRIST, J. Paul2 ; MILLER, Thomas A1
[1] Department of Drug Design and Optimization-Medicinal Chemistry, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States
[2] Department of Cancer Biology and Therapeutics, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States
[3] Department of Drug Design and Optimization-Automated Lead Optimization, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 1, pp 34-38, 5 p ; ref : 10 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Amino acid Benzothiophene Cancer Histone deacetylase Lysine Ugi reaction
- Keyword (fr)
- Acide hydroxamique Aminoacide Anilide Anticancéreux Carboxamide Cellule tumorale Côlon Dérivé de la benzamide Dérivé de la pipérazine Dérivé du benzothiophène Homme Hydrolases In vitro Inhibiteur enzyme Inhibiteur histone deacetylase Lignée cellulaire Relation structure activité Réaction Ugi Synthèse chimique Tumeur maligne Tumeur solide Vorinostat α-Aminoacide Benzo[b]thiophène-2-carboxamide dérivé Heptanohydroxamique acide(7-phénylcarbamoyl) Histone deacetylase Lignée HCT116 Lysine dérivé Phénylalanine dérivé Phénylglycine dérivé Cancer Enzyme
- Keyword (en)
- Hydroxamic acid Aminoacid Anilide Antineoplastic agent Carboxamide Tumor cell Colon Benzamide derivatives Piperazine derivatives Benzothiophene derivatives Human Hydrolases In vitro Enzyme inhibitor Histone deacetylase inhibitor Cell line Structure activity relation Ugi reaction Chemical synthesis Malignant tumor Solid tumor Vorinostat α-Aminoacid Cancer Enzyme
- Keyword (es)
- Acido hidroxámico Aminoácido Anilido Anticanceroso Carboxamida Célula tumoral Colón Benzamida derivado Piperazina derivado Benzotiofeno derivado Hombre Hydrolases In vitro Inhibidor enzima Inhibidor histone deacetylase Línea celular Relación estructura actividad Reacción Ugi Síntesis química Tumor maligno Tumor sólido Vorinostat α-Aminoácido Cáncer Enzima
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20037385
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2007.11.017 
https://dx.doi.org/10.1016/j.bmcl.2007.11.017
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