Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives
- Author
- ZAGOTTO, Giuseppe1 ; SISSI, Claudia1 ; MORO, Stefano1 ; DAL BEN, Diego2 ; PARKINSON, Gary N3 ; FOX, Keith R4 ; NEIDLE, Stephen3 ; PALUMBO, Manlio1
[1] Department of Pharmaceutical Sciences, University of Padova, Via Marzolo, 5, 35131 Padova, Italy
[2] Department of Chemical Sciences, University of Camerino, Via S.Agostino, 1, 62032 Camerino(MC), Italy
[3] CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, United Kingdom
[4] School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, United Kingdom - Source
Bioorganic & medicinal chemistry. 2008, Vol 16, Num 1, pp 354-361, 8 p ; ref : 15 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Anthracenedione Cancer G-quadruplex Telomerase
- Keyword (fr)
- Analyse conformationnelle Carboxamide Composé benzénique condensé Composé tricyclique Dérivé de l'anthraquinone Fixation biologique Guanine In vitro Inhibiteur enzyme Interaction moléculaire Modèle moléculaire Modélisation Nucleotidyltransferases Quinone Relation structure activité Spécificité séquence Synthèse chimique Séquence nucléotide Telomerase Télomère Quadruplexe G Enzyme Transferases
- Keyword (en)
- Conformational analysis Carboxamide Condensed benzenic compound Tricyclic compound Anthraquinone derivatives Biological fixation Guanine In vitro Enzyme inhibitor Molecular interaction Molecular model Modeling Nucleotidyltransferases Quinone Structure activity relation Sequence specificity Chemical synthesis Nucleotide sequence Telomerase Telomere Enzyme Transferases
- Keyword (es)
- Análisis conformacional Carboxamida Compuesto bencénico condensado Compuesto tricíclico Antraquinona derivado Fijación biológica Guanina In vitro Inhibidor enzima Interacción molecular Modelo molecular Modelización Nucleotidyltransferases Quinona Relación estructura actividad Espicificidad secuencia Síntesis química Secuencia nucleótido Telomerase Telómero Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20056167
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2007.09.040 
https://dx.doi.org/10.1016/j.bmc.2007.09.040
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