Small P-gp modulating molecules : SAR studies on tetrahydroisoquinoline derivatives
- Author
- COLABUFO, Nicola Antonio1 ; BERARDI, Francesco1 ; PORCELLI, Letizia2 ; PARADISO, Angelo2 ; CANTORE, Mariangela1 ; GRAZIA PERRONE, Maria1 ; CONTINO, Marialessandra1 ; INGLESE, Carmela1 ; NISO, Mauro1 ; PERRONE, Roberto1 ; AZZARITI, Amalia2 ; SIMONE, Grazia Maria2
[1] Dipartimento Farmacochimico, Uniuersità degli Studi di Bari, via Orabona, 4, 70125 Bari, Italy
[2] National Cancer Institute Giovanni Paolo II, Via Hahnemann, 10, 70126 Bari, Italy - Source
Bioorganic & medicinal chemistry. 2008, Vol 16, Num 1, pp 362-373, 12 p ; ref : 61 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Caco-2 cells MCF-7/Adr cells P-Glycoprotein P-gp inhibitors Tetrahydroisoquinoline derivatives Vinblastine transport
- Keyword (fr)
- Alcaloïde Anticancéreux Association médicamenteuse Cellule tumorale Chimiosensibilisant Composé aromatique Composé bicyclique Cytotoxicité Côlon Diéther Doxorubicine Dérivé de l'isoquinoléine Dérivé du naphtalène Ether Glande mammaire Glycoprotéine P Homme Hétérocycle azote In vitro Inhibition Lignée cellulaire Mécanisme action Perméabilité cellulaire Protéine transmembranaire Protéine transport Relation structure activité Résistance multiple Réversibilité Synthèse chimique Vinblastine Isoquinoléine(6,7-diméthoxy-2-[3-(5-méthoxy-1,2,3,4-tétrahydro-1-napthylidène)propyl]-1,2,3,4-tétrahydro) Lignée CACO2 Lignée MCF7 Anthracyclines Antimitotique DNA topoisomerase (ATP-hydrolysing) Enzyme Inhibiteur enzyme Isomerases
- Keyword (en)
- Alkaloid Antineoplastic agent Drug combination Tumor cell Chemosensitizing agent Aromatic compound Bicyclic compound Cytotoxicity Colon Diether Doxorubicin Isoquinoline derivatives Naphthalene derivatives Ether Mammary gland P Glycoprotein Human Nitrogen heterocycle In vitro Inhibition Cell line Mechanism of action Cell permeability Transmembrane protein Carrier protein Structure activity relation Multiple resistance Reversibility Chemical synthesis Vinblastine Anthracyclins Antimitotic DNA topoisomerase (ATP-hydrolysing) Enzyme Enzyme inhibitor Isomerases
- Keyword (es)
- Alcaloide Anticanceroso Asociación medicamentosa Célula tumoral Quimiosensibilizante Compuesto aromático Compuesto bicíclico Citotoxicidad Colón Dieter Doxorubicina Isoquinoleína Naftaleno derivado Eter Glándula mamaria Glicoproteína P Hombre Heterociclo nitrógeno In vitro Inhibición Línea celular Mecanismo acción Permeabilidad celular Proteína transmembranar Proteína transportador Relación estructura actividad Resistencia múltiple Reversibilidad Síntesis química Vinblastina Antraciclinas Antimitótico DNA topoisomerase (ATP-hydrolysing) Enzima Inhibidor enzima Isomerases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20056168
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2007.09.039 
https://dx.doi.org/10.1016/j.bmc.2007.09.039
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