Trypanosoma cruzi : Activities of lapachol and α-and β-lapachone derivatives against epimastigote and trypomastigote forms
- Author
- SALAS, Cristian1 ; TAPIA, Ricardo A1 ; CIUDAD, Karina1 ; ARMSTRONG, Veronica1 ; ORELLANA, Myriam2 ; KEMMERLING, Ulrike2 ; FERREIRA, Jorge2 ; DIEGO MAYA, Juan2 ; MORELLO, Antonio2
[1] Departamento de Química Orgánica, Facultad de Quimica, Pontificia Universidad Católica de Chile, Av. Vicuna Mackenna 4860, Macul, Santiago 6094411, Chile
[2] Departamento de Farmacología Molecular y Clínica, Facultad de Medicina, Universidad de Chile, Santiago, Chile - Source
Bioorganic & medicinal chemistry. 2008, Vol 16, Num 2, pp 668-674, 7 p ; ref : 35 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Anti-trypanosomal activity Lapachol derivatives Oxidative stress Redox cycling α- and β-Lapachone derivatives
- Keyword (fr)
- Antiparasitaire Antiprotozoaire Composé benzénique condensé Composé bicyclique Composé tricyclique Dérivé de la naphtoquinone Epimastigote Hétérocycle oxygène In vitro Isomère position Lapachol Mécanisme action Quinone Relation structure activité Stress oxydatif Synthèse chimique Trypanosoma cruzi Trypomastigote Naphto[1,2-b]pyrane-5,6-dione dérivé Naphto[2,3-b]pyrane-5,10-dione dérivé Naphtopyrane α-Lapachone β-Lapachone Kinetoplastida Protozoa
- Keyword (en)
- Parasiticide Antiprotozoal agent Condensed benzenic compound Bicyclic compound Tricyclic compound Naphthoquinone derivatives Epimastigote Oxygen heterocycle In vitro Position isomer Mechanism of action Quinone Structure activity relation Oxidative stress Chemical synthesis Trypanosoma cruzi Trypomastigote Kinetoplastida Protozoa
- Keyword (es)
- Antiparasitario Antiprotozoario Compuesto bencénico condensado Compuesto bicíclico Compuesto tricíclico Epimastigota Heterociclo oxígeno In vitro Isómero posición Mecanismo acción Quinona Relación estructura actividad Estrés oxidativo Síntesis química Trypanosoma cruzi Tripomastigota Kinetoplastida Protozoa
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S06 Antiparasitic agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20056230
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2007.10.038 
https://dx.doi.org/10.1016/j.bmc.2007.10.038
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