A phase I and pharmacokinetic study of OSI-7904L, a liposomal thymidylate synthase inhibitor in combination with oxaliplatin in patients with advanced colorectal cancer
- Author
- CLAMP, A. R1 ; SCHOFFSKI, P2 ; JAYSON, G. C1 ; VALLE, J. W1 ; WILSON, R. H3 ; MARREAUD, S4 ; GOVAERTS, A.-S4 ; DEBOIS, M4 ; LACOMBE, D4 ; TWELVES, C4 ; CHICK, J5
[1] Cancer Research UK and University of Manchester Department of Medical Oncology, Christie Hospital, Wilmslow Road, Manchester M20 4BX, United Kingdom
[2] Department of Hematology, Hemostaseology and Oncology, Hannover Medical School, Hannover, Germany
[3] Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast BT9 7AB, United Kingdom
[4] EORTC New Drug Development Program (NDDP), Brussels, Belgium
[5] OSI Pharmaceuticals Inc, Oxford, United Kingdom
EORTC New Drug Development Group, United Kingdom - Source
Cancer chemotherapy and pharmacology. 2008, Vol 61, Num 4, pp 579-585, 7 p ; ref : 26 ref
- CODEN
- CCPHDZ
- ISSN
- 0344-5704
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- Springer, Berlin
- Publication country
- Germany
- Document type
- Article
- Language
- English
- Author keyword
- Colorectal carcinoma OSI-7904L Oxaliplatin Phase I Thymidylate synthase
- Keyword (fr)
- Anticancéreux Association médicamenteuse Cancer colorectal Carcinome colorectal Homme Inhibiteur Liposome Oxaliplatine Pharmacocinétique Stade avancé Thymidylate synthase Agent alkylant Cancer Enzyme Methyltransferases Pathologie de l'appareil digestif Pathologie de l'intestin Pathologie du côlon Pathologie du rectum Platine II Complexe Transferases Tumeur maligne
- Keyword (en)
- Antineoplastic agent Drug combination Colorectal cancer Colorectal carcinoma Human Inhibitor Liposome Oxaliplatin Pharmacokinetics Advanced stage Thymidylate synthase Alkylating agent Cancer Enzyme Methyltransferases Digestive diseases Intestinal disease Colonic disease Rectal disease Platinum II Complexes Transferases Malignant tumor
- Keyword (es)
- Anticanceroso Asociación medicamentosa Cancer de colon y recto Carcinoma colorectal Hombre Inhibidor Liposoma Oxaliplatino Farmacocinética Estadio avanzado Thymidylate synthase Agente alquilante Cáncer Enzima Methyltransferases Aparato digestivo patología Intestino patología Colón patología Recto patología Platino II Complejo Transferases Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13B Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / 002B13B01 Tumors
- Discipline
- Gastroenterology. Liver. Pancreas. Abdomen Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20056567
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1007/s00280-007-0509-5 
https://dx.doi.org/10.1007/s00280-007-0509-5
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