A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine
- Author
- VAN VLIET, Erwin1 ; MORATH, Siegfried1 ; ESKES, Chantra1 ; LINGE, Jens1 ; RAPPSILBER, Juri2 ; HONEGGER, Paul3 ; HARTUNG, Thomas1 ; COECKE, Sandra1
[1] ECVAM, Institute for Health & Consumer Protection, European Commission Joint Research Centre, 21020 Ispra (VA), Italy
[2] The FIRC Institute of Molecular Oncology Foundation (IFOM), Via Adamello 16, 20139 Milan, Italy
[3] Institute Institute of Physiology, University of Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland - Source
Neurotoxicology (Park Forest South). 2008, Vol 29, Num 1, pp 1-12, 12 p ; ref : 1 p.1/4
- ISSN
- 0161-813X
- Scientific domain
- Neurology; Toxicology
- Publisher
- Elsevier, Orlando, FL
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- Biomarkers Caffeine Metabolomics Methyl mercury chloride Principal component analysis Re-aggregating brain cell cultures
- Keyword (fr)
- Analeptique respiratoire Analyse composante principale Caféine Cerveau Chlorure de mercure Culture cellulaire Dépistage Encéphale In vitro Marqueur biologique Méthane(chloro) Neurotoxicité Pathologie du système nerveux Psychotrope Stimulant SNC Système nerveux Toxicité Mercure chlorure Mercure(méthyl) Dérivé de la xanthine Métal lourd Système nerveux central
- Keyword (en)
- Respiratory analeptic Principal component analysis Caffeine Brain Mercury chloride Cell culture Medical screening Encephalon In vitro Biological marker Methyl chloride Neurotoxicity Nervous system diseases Psychotropic CNS stimulant Nervous system Toxicity Xanthine derivatives Heavy metal Central nervous system
- Keyword (es)
- Analéptico respiratorio Análisis componente principal Cafeína Cerebro Mercurio cloruro Cultivo celular Descubrimiento Encéfalo In vitro Marcador biológico Metano(cloro) Neurotoxicidad Sistema nervioso patología Psicotropo Estimulante SNC Sistema nervioso Toxicidad Xantina derivado Metal pesado Sistema nervioso central
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B03 Toxicology / 002B03L Chemical and industrial products toxicology. Toxic occupational diseases / 002B03L05 Metals and various inorganic compounds
- Discipline
- Toxicology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20062804
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.neuro.2007.09.007 
https://dx.doi.org/10.1016/j.neuro.2007.09.007
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