Simultaneous determination of gemcitabine and its main metabolite, dFdU, in plasma of patients with advanced non-small-cell lung cancer by high-performance liquid chromatography-tandem mass spectrometry
- Author
- MARANGON, Elena1 ; SALA, Federica1 ; CAFFO, Orazio2 ; GALLIGIONI, Enzo2 ; D'INCALCI, Maurizio1 ; ZUCCHETTI, Massimo1
[1] Laboratory of Cancer Pharmacology, Department of Oncology, Istituto di Ricerche Farmacologiche 'Mario Negri', via la masa 19, 20156 Milan, Italy
[2] UO Medical Oncology, Santa Chiara Hospital, Trento, Italy - Source
Journal of mass spectrometry. 2008, Vol 43, Num 2, pp 216-223, 8 p ; ref : 19 ref
- ISSN
- 1076-5174
- Scientific domain
- Biochemistry, molecular biology, biophysics; Analytical chemistry; Organic chemistry
- Publisher
- Wiley, Chichester
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- HPLC-MS/MS gemcitabine human pharmacokinetics non-small-cell lung cancer
- Keyword (fr)
- Analyse chimique Anticancéreux Carcinome non petite cellule bronchopulmonaire Chromatographie HPLC Gemcitabine Homme Liquide biologique Malade Mesure simultanée Métabolite Méthode couplée Pharmacocinétique Plasma sanguin Sang LC MS MS Spectrométrie masse tandem Antimétabolite Cancer Fluor composé organique Pathologie de l'appareil respiratoire Pathologie des bronches Pathologie des poumons Pyrimidine nucléoside Tumeur maligne
- Keyword (en)
- Chemical analysis Antineoplastic agent non-small cell lung carcinoma HPLC chromatography Gemcitabine Human Biological fluid Patient Simultaneous measurement Metabolite Coupled method Pharmacokinetics Blood plasma Blood Tandem mass spectrometry Antimetabolic Cancer Organic fluorine compounds Respiratory disease Bronchus disease Lung disease Pyrimidine nucleoside Malignant tumor
- Keyword (es)
- Análisis químico Anticanceroso Carcinoma no pequeňa célula bronchopulmonar Cromatografía HPLC Gemcitabina Hombre Líquido biológico Enfermo Medición simultánea Metabolito Método acoplado Farmacocinética Plasma sanguíneo Sangre Espectrometría masa en tándem Antimetabólito Cáncer Aparato respiratorio patología Bronquio patología Pulmón patología Pirimidina nucleósido Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A02 Analysis
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20065522
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1002/jms.1293 
https://dx.doi.org/10.1002/jms.1293
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