Simultaneous determination of simvastatin and simvastatin acid in human plasma by LC-MS/MS without polarity switch : Application to a bioequivalence study
- Author
- PATEL, Bhavin N1 2 ; SHARMA, Naveen2 ; SANYAL, Mallika3 ; SHRIVASTAV, Pranav S1
[1] Chemistry Department, School of Sciences, Gujarat University, Navrangpura, Ahmedabad, India
[2] Analytical Laboratory, BA Research India Ltd., Bodakdev, Ahmedabad, India
[3] Chemistry Department, St. Xaviers' College, Navrangpura, Ahmedabad, India - Source
Journal of separation science. 2008, Vol 31, Num 2, pp 301-313, 13 p ; ref : 19 ref
- ISSN
- 1615-9306
- Scientific domain
- Biochemistry, molecular biology, biophysics; Analytical chemistry; Pharmacology drugs
- Publisher
- Wiley, Weinheim
- Publication country
- Germany
- Document type
- Article
- Language
- English
- Author keyword
- Flash freezing Human plasma LC-MS/MS Simvastatin acid Simvastatin
- Keyword (fr)
- Analyse chimique Analyse quantitative Bioéquivalence Chromatographie HPLC Extraction liquide liquide Extraction solvant Homme Hypolipémiant Liquide biologique Mesure simultanée Métabolite Méthode couplée Pharmacocinétique Plasma sanguin Préparation échantillon Sang Simvastatine Validation Voie orale LC MS MS Spectrométrie masse tandem Dérivé de la statine Enzyme Hydroxymethylglutaryl-CoA reductase Inhibiteur enzyme Oxidoreductases
- Keyword (en)
- Chemical analysis Quantitative analysis Bioequivalence HPLC chromatography Liquid liquid extraction Solvent extraction Human Antilipemic agent Biological fluid Simultaneous measurement Metabolite Coupled method Pharmacokinetics Blood plasma Sample preparation Blood Simvastatin Validation Oral administration Tandem mass spectrometry Statin derivative Enzyme Hydroxymethylglutaryl-CoA reductase Enzyme inhibitor Oxidoreductases
- Keyword (es)
- Análisis químico Análisis cuantitativo Bioequivalencia Cromatografía HPLC Extracción líquido líquido Extracción solvente Hombre Hipolipemiante Líquido biológico Medición simultánea Metabolito Método acoplado Farmacocinética Plasma sanguíneo Preparación muestreo Sangre Simvastatina Validación Vía oral Espectrometría masa en tándem Statina derivado Enzima Hydroxymethylglutaryl-CoA reductase Inhibidor enzima Oxidoreductases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A02 Analysis
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20069086
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1002/jssc.200700367 
https://dx.doi.org/10.1002/jssc.200700367
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