Meriolins (3-(Pyrimidin-4-yl)-7-azaindoles) : Synthesis, Kinase Inhibitory Activity, Cellular Effects, and Structure of a CDK2/Cyclin A/Meriolin Complex
- Author
- ECHALIER, Aude1 ; BETTAYEB, Karima2 ; JOSEPH, Benoit5 ; MEIJER, Laurent2 ; FERANDIN, Yoan2 ; LOZACH, Olivier2 ; CLEMENT, Monique3 ; VALETTE, Annie4 ; LIGER, Francois5 ; MARQUET, Bernard5 ; MORRIS, Jonathan C6 ; ENDICOTT, Jane A1
[1] Laboratory of Molecular Biophysics and Department of Biochemistry, The Rex Richards Building, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom
[2] C.N.R.S., Cell Cycle Group & UPS2682, Station Biologique, B.P. 74, 29682 Roscoff Bretagne, France
[3] Département de Recherches en Cancérologie, Université de Nantes, Inserm U692, 9 Quai Moncousu, 44093 Nantes, France
[4] LBCMCP, UMR-CNRS 5088, IFR 109, Université Paul Sabatier Bat 4R3B1, 118 Route de Narbonne, 31062 Toulouse, France
[5] Laboratoire de Chimie Organique 1, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, UMR-CNRS 5246, Uniuersité de Lyon, France
[6] Department of Chemistry, School of Chemistry and Physics, University of Adelaide, Adelaide SA 5005, Australia
[7] Universite Claude Bemard-Lyon 1, Bâtiment Curien, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne, France - Source
Journal of medicinal chemistry (Print). 2008, Vol 51, Num 4, pp 737-751, 15 p ; ref : 88 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Cellule tumorale Côlon Dérivé de la pyrimidine Embryon Homme In vitro Inhibiteur enzyme Kinase cycline dépendante Lignée cellulaire Mode liaison Modèle moléculaire Modélisation Myélome Neuroblastome Rein Relation structure activité Synthèse chimique Tumeur solide Lignée HCT116 Lignée HEK293 Lignée KMS11 Lignée LS174T Lignée SHSY5Y Merioline Pyrrolo[2,3-b]pyridine dérivé Pyrrolo[2,3-b]pyridine(3-[2-aminopyrimidin-4-yl]-1-benzènesulfonyl-4-chloro) Pyrrolopyridine Enzyme Transferases
- Keyword (en)
- Tumor cell Colon Pyrimidine derivatives Embryo Human In vitro Enzyme inhibitor Cyclin dependent kinase Cell line Binding mode Molecular model Modeling Myeloma Neuroblastoma Kidney Structure activity relation Chemical synthesis Solid tumor Enzyme Transferases
- Keyword (es)
- Célula tumoral Colón Pirimidina derivado Embrión Hombre In vitro Inhibidor enzima Cyclin dependent kinase Línea celular Modo de enlace Modelo molecular Modelización Mieloma Neuroblastoma Riñón Relación estructura actividad Síntesis química Tumor sólido Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20117778
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm700940h 
https://dx.doi.org/10.1021/jm700940h
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