A phase I dose escalation study off BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor I (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours
- Author
- ESKENS, F. A. L. M1 ; MOM, C. H2 ; DE VRIES, E. G. E2 ; PLANTING, A. S. T1 ; GIETEMA, J. A2 ; AMELSBERG, A3 ; HUISMAN, H4 ; VAN DOORN, L1 ; BURGER, H1 ; STOPFER, P5 ; VERWEIJ, J1
[1] Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, Netherlands
[2] Department of Medical Oncology, University Hospital, Groningen, Netherlands
[3] Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, United States
[4] Boehringer Ingelheim BV, Alkmaar, Netherlands
[5] Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany - Source
British journal of cancer. 2008, Vol 98, Num 1, pp 80-85, 6 p ; ref : 3/4 p
- CODEN
- BJCAAI
- ISSN
- 0007-0920
- Scientific domain
- Medical oncology
- Publisher
- Nature Publishing Group, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- BIBW 2992 epidermal growth factor receptor pharmacokinetics phase I tyrosine kinase inhibitor
- Keyword (fr)
- Cancérologie Dose croissante Essai clinique phase I Gène erbB2 Gène onc cellulaire Homme Inhibiteur Irréversible Pharmacocinétique Protein-tyrosine kinase Protooncogène Récepteur facteur croissance épiderme Récepteur facteur croissance Stade avancé Traitement Tumeur solide Récepteur HER2 Cancer Enzyme Transferases Tumeur maligne
- Keyword (en)
- Cancerology Increasing dose Phase I trial erbB2 Gene C-Onc gene Human Inhibitor Irreversible Pharmacokinetics Protein-tyrosine kinase Protooncogene Epidermal growth factor receptor Growth factor receptor Advanced stage Treatment Solid tumor Human Epidermal growth factor Receptor 2 Cancer Enzyme Transferases Malignant tumor
- Keyword (es)
- Cancerología Dosis creciente Ensayo clínico fase I Gen erbB2 Gen onc celular Hombre Inhibidor Irreversible Farmacocinética Protein-tyrosine kinase Protooncogen Receptor del factor de crecimiento epidérmico Receptor factor crecimiento Estadio avanzado Tratamiento Tumor sólido Cáncer Enzima Transferases Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04C Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
- Discipline
- Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20133918
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/sj.bjc.6604108 
https://dx.doi.org/10.1038/sj.bjc.6604108
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