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A novel sesquiterpenoid dimer parviflorene F induces apoptosis by up-regulating the expression of TRAIL-R2 and a caspase-dependent mechanism

Author
OHTSUKI, Takashi1 ; TAMAKI, Mayu1 ; TOUME, Kazuhumi1 ; ISHIBASHI, Masami1
[1] Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan
Source

Bioorganic & medicinal chemistry. 2008, Vol 16, Num 4, pp 1756-1763, 8 p ; ref : 29 ref

ISSN
0968-0896
Scientific domain
Biochemistry, molecular biology, biophysics; Pharmacology drugs
Publisher
Elsevier Science, Oxford
Publication country
United Kingdom
Document type
Article
Language
English
Author keyword
Apoptosis Caspase Sesquiterpenoid dimer TRAIL-R2
Keyword (fr)
Activité biologique Apoptose Caspase Cellule tumorale Col utérus Cysteine endopeptidases Dimère Homme Isolement Ligand TRAIL Lignée HeLa Lignée cellulaire Mécanisme action Origine végétale Pharmacognosie Phénols Plante médicinale Sesquiterpène Terpénoïde Transduction signal Zingiberaceae Curcuma parviflora Dibenzo[a,h]anthracène dérivé Dibenzoanthracène Parviflorene F Angiospermae Enzyme Hydrolases Monocotyledones Peptidases Spermatophyta
Keyword (en)
Biological activity Apoptosis Caspase Tumor cell Uterine cervix Cysteine endopeptidases Dimer Human Isolation TNF related apoptosis inducing ligand Hela cell line Cell line Mechanism of action Plant origin Pharmacognosy Phenols Medicinal plant Sesquiterpenes Terpenoid Signal transduction Zingiberaceae Angiospermae Enzyme Hydrolases Monocotyledones Peptidases Spermatophyta
Keyword (es)
Actividad biológica Apoptosis Caspase Célula tumoral Cuello útero Cysteine endopeptidases Dímero Hombre Aislamiento Ligando TRAIL Célula HeLa Línea celular Mecanismo acción Origen vegetal Farmacognosia Fenoles Planta medicinal Sesquiterpeno Terpenoide Transducción señal Zingiberaceae Angiospermae Enzima Hydrolases Monocotyledones Peptidases Spermatophyta
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A04 Pharmacognosy. Homeopathy. Health food

Discipline
General pharmacology
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
20140906

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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