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A physiologically based pharmacokinetic (PBPK) model to characterize and predict the disposition of monoclonal antibody CC49 and its single chain Fv constructs

Author
DAVDA, Jasmine P1 ; JAIN, Maneesh2 ; SATRA, Surinder K2 ; GWILT, Peter R1 ; ROBINSON, Dennis H1
[1] Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198-6025, United States
[2] Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198-5870, United States
Source

International immunopharmacology. 2008, Vol 8, Num 3, pp 401-413, 13 p ; ref : 42 ref

ISSN
1567-5769
Scientific domain
Immunology, immunopathology, allergology; Pharmacology drugs
Publisher
Elsevier, Amsterdam
Publication country
Netherlands
Document type
Article
Language
English
Author keyword
Antibody pharmacokinetics FcRn IgG PBPK modeling Tumor radioimmunotherapy scFvs
Keyword (fr)
Anticorps monoclonal Anticorps simple chaîne Facteur prédictif IgG Immunoradiothérapie Modèle PBPK Pharmacocinétique Traitement Tumeur maligne Cancer Radiothérapie
Keyword (en)
Monoclonal antibody Single chain antibody Predictive factor IgG Immunoradiotherapy Physiologically based pharmacokinetic model Pharmacokinetics Treatment Malignant tumor Cancer Radiotherapy
Keyword (es)
Anticuerpo monoclonal Anticuerpo simple cadena Factor predictivo IgG Inmunoradioterapia PBPK modelo Farmacocinética Tratamiento Tumor maligno Cáncer Radioterapia
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments

Discipline
General pharmacology
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
20144550

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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