The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
- Author
- CHRISTOFK, Heather R1 ; VANDER HEIDEN, Matthew G1 2 ; HARRIS, Marian H3 ; RAMANATHAN, Arvind4 ; GERSZTEN, Robert E4 5 6 ; RU WEI4 ; FLEMING, Mark D3 ; SCHREIBER, Stuart L4 7 ; CANTLEY, Lewis C1 8
[1] Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States
[2] Dana Farber Cancer Institute, Boston, Massachusetts 02115, United States
[3] Department of Pathology, Children's Hospital, Boston, Massachusetts 02115, United States
[4] Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, United States
[5] cardiology Division and Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Massachusetts 02129, United States
[6] Donald W. Reynolds Cardiovascular Clinical Research Center on Atherosclerosis, Harvard Medical School, Boston, Massachusetts 02115, United States
[7] Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States
[8] Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, United States - Source
Nature (London). 2008, Vol 452, Num 7184, pp 230-233, 4 p ; ref : 19 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Aérobie Cancérologie Carcinogenèse Croissance tumorale Epissage alternatif Glycolyse Homme Isozyme Métabolisme Pyruvate kinase Souris Tumeur maligne Variant génétique Cancer Enzyme Génétique Mammalia Rodentia Transferases Vertebrata
- Keyword (en)
- Animal Aerobe Cancerology Carcinogenesis Tumor growth Alternative splicing Glycolysis Human Isozyme Metabolism Pyruvate kinase Mouse Malignant tumor Genetic variant Cancer Enzyme Genetics Mammalia Rodentia Transferases Vertebrata
- Keyword (es)
- Animal Aerobio Cancerología Carcinogénesis Crecimiento tumoral Empalme alternativo Glicolisis Hombre Isozima Metabolismo Pyruvate kinase Ratón Tumor maligno Variante genética Cáncer Enzima Genética Mammalia Rodentia Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04E Carcinogenesis, carcinogens and anticarcinogens / 002B04E01 General aspects
- Discipline
- Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20161711
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature06734 
https://dx.doi.org/10.1038/nature06734
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