A potential new prodrug for the treatment of cystinosis : Design, synthesis and in-vitro evaluation
- Author
- MCCAUGHAN, Bridgeen1 ; KAY, Graeme1 ; KNOTT, Rachel M1 ; CAIRNS, Donald1
[1] School of Pharmacy, The Robert Gordon University, Scotland, Aberdeen, Aberdeenshire AB10 1FR, United Kingdom - Source
Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 5, pp 1716-1719, 4 p ; ref : 19 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Cystinosis Prodrug Treatment
- Keyword (fr)
- Activité biologique Carboxamide Cellule endothéliale Composé aliphatique Cordon ombilical Cystinose Cytotoxicité Fibroblaste Homme In vitro Lignée cellulaire Promédicament Synthèse chimique Toxicité Traitement Vaisseau sanguin Décanamide dérivé HUV Lignée HUVEC Aminoacidopathie Enzymopathie Maladie héréditaire Maladie métabolique Pathologie des lysosomes Thésaurismose
- Keyword (en)
- Biological activity Carboxamide Endothelial cell Aliphatic compound Umbilical cord Cystinosis Cytotoxicity Fibroblast Human In vitro Cell line Prodrug Chemical synthesis Toxicity Treatment Blood vessel Aminoacid disorder Enzymopathy Genetic disease Metabolic diseases Lysosomal storage disease Storage disease
- Keyword (es)
- Actividad biológica Carboxamida Célula endotelial Compuesto alifático Cordón umbilical Cistinosis Citotoxicidad Fibroblasto Hombre In vitro Línea celular Promedicamento Síntesis química Toxicidad Tratamiento Vaso sanguíneo Aminoacido alteración Enzimopatía Enfermedad hereditaria Metabolismo patología Lisosoma patología Tesaurosis
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20167650
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2008.01.039 
https://dx.doi.org/10.1016/j.bmcl.2008.01.039
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