Simvastatin antagonizes tumor necrosis factor-a inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway
- Author
- YAMASHITA, Misuzu1 ; OTSUKA, Fumio1 ; MUKAI, Tomoyuki2 ; OTANI, Hiroyuki1 ; INAGAKI, Kenichi1 ; MIYOSHI, Tomoko1 ; GOTO, Junko1 ; YAMAMURA, Masahiro2 ; MAKINO, Hirofumi1
[1] Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan
[2] Department of Rheumatology, School of Medicine, Aichi Medical University, Aichi 480-1195, Japan - Source
Journal of endocrinology. 2008, Vol 196, Num 3, pp 601-613, 13 p ; ref : 1 p.1/4
- CODEN
- JOENAK
- ISSN
- 0022-0795
- Scientific domain
- Endocrinology
- Publisher
- Portland Press, Colchester
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Analyse quantitative Expression génique Facteur nécrose tumorale Lignée cellulaire Mitogen-activated protein kinase Muscle strié Os Protéine Smad Protéine morphogénétique osseuse Simvastatine Souris Transduction signal Lignée C2C12 Cytokine Enzyme Inflammation Mammalia Ostéoblaste Rodentia Système ostéoarticulaire Transferases Vertebrata
- Keyword (en)
- Quantitative analysis Gene expression Tumor necrosis factor Cell line Mitogen-activated protein kinase Striated muscle Bone Smad protein Bone morphogenetic protein Simvastatin Mouse Signal transduction Cytokine Enzyme Inflammation Mammalia Osteoblast Rodentia Osteoarticular system Transferases Vertebrata
- Keyword (es)
- Análisis cuantitativo Expresión genética Factor necrosis tumoral Línea celular Mitogen-activated protein kinase Músculo estriado Hueso Proteína Smad Proteína morfogenética ósea Simvastatina Ratón Transducción señal Citoquina Enzima Inflamación Mammalia Osteoblasto Rodentia Sistema osteoarticular Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A23 Vertebrates: osteoarticular system, musculoskeletal system / 002A23C Miscellaneous
- Discipline
- Vertebrates : osteoarticular system, musculoskeletal system
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20200651
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1677/JOE-07-0532 
https://dx.doi.org/10.1677/JOE-07-0532
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