A Phase 1 dose-escalation trial of glufosfamide in combination with gemcitabine in solid tumors including pancreatic adenocarcinoma
- Author
- GABRIELA CHIOREAN, E1 ; DRAGOVICH, Tomislav2 ; HAMM, John3 ; LANGMUIR, Virginia K4 ; KROLL, Stewart4 ; JUNG, Donald T4 ; COLOWICK, Alan B4 ; TIDMARSH, George F4 ; LOEHRER, Patrick J1
[1] Indiana University Cancer Center, 535 Barnhill Drive, Room 414, Indianapolis, IN 46202, United States
[2] Arizona Cancer Center, Tucson, AZ, United States
[3] Norton Health Care, Louisville, KY, United States
[4] Threshold Pharmaceuticals, Redwood City, CA, United States - Source
Cancer chemotherapy and pharmacology. 2008, Vol 61, Num 6, pp 1019-1026, 8 p ; ref : 13 ref
- CODEN
- CCPHDZ
- ISSN
- 0344-5704
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- Springer, Berlin
- Publication country
- Germany
- Document type
- Article
- Language
- English
- Author keyword
- Combination chemotherapy Gemcitabine Glufosfamide Pancreatic cancer Phase I Targeted therapy
- Keyword (fr)
- Anticancéreux Association médicamenteuse Cancer du pancréas Dose croissante Essai clinique Gemcitabine Glufosfamide Thérapeutique ciblée Traitement associé Tumeur solide Escalade de dose Tumeur pancréas Antimétabolite Cancer Dérivé de l'oxazaphosphinane Dérivé de la pyrimidine Fluor Composé organique Pathologie de l'appareil digestif Pathologie du pancréas Pyrimidine nucléoside Tumeur maligne
- Keyword (en)
- Antineoplastic agent Drug combination Pancreas cancer Increasing dose Clinical trial Gemcitabine Glufosfamide Targeted therapy Combined treatment Solid tumor Dose escalation Pancreatic tumor Antimetabolic Cancer Oxazaphosphinane derivatives Pyrimidine derivatives Fluorine Organic compounds Digestive diseases Pancreatic disease Pyrimidine nucleoside Malignant tumor
- Keyword (es)
- Anticanceroso Asociación medicamentosa Cáncer del páncreas Dosis creciente Ensayo clínico Gemcitabina Glufosfamida Terapéutica dirigida Tratamiento asociado Tumor sólido Antimetabólito Cáncer Oxazafosfinano derivado Pirimidina derivado Fluor Compuesto orgánico Aparato digestivo patología Páncreas patología Pirimidina nucleósido Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04C Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13C Liver. Biliary tract. Portal circulation. Exocrine pancreas / 002B13C01 Tumors
- Discipline
- Gastroenterology. Liver. Pancreas. Abdomen Pharmacological treatments Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20200955
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1007/s00280-007-0559-8 
https://dx.doi.org/10.1007/s00280-007-0559-8
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