Direct mitochondrial dysfunction precedes reactive oxygen species production in amiodarone-induced toxicity in human peripheral lung epithelial HPL1A cells
- Author
- NICOLESCU, Adrian C1 ; YANBIN JI1 ; COMEAU, Jeannette L1 ; HILL, Bruce C2 ; TAKAHASHI, Takashi3 ; BRIEN, James F1 ; RACZ, William J1 ; MASSEY, Thomas E1
[1] Department of Pharmacology and Toxicology, Queen's University, Kingston, ON, K7L 3N6, Canada
[2] Department of Biochemistry, Queen's University, Kingston, ON, K7L 3N6, Canada
[3] Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan - Source
Toxicology and applied pharmacology. 2008, Vol 227, Num 3, pp 370-379, 10 p ; ref : 1 p.1/4
- CODEN
- TXAPA9
- ISSN
- 0041-008X
- Scientific domain
- Pharmacology drugs; Toxicology
- Publisher
- Elsevier, San Diego, CA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- Amiodarone Aryl radicals Cytochrome c Electron paramagnetic resonance spectroscopy Lung epithelial cells Mitochondria N-Desethylamiodarone Pulmonary toxicity
- Keyword (fr)
- Amiodarone Antiangoreux Antiarythmique Biosynthèse Cellule épithéliale Cytochrome c Espèces réactives de l'oxygène Homme In vitro Mitochondrie Poumon Radical libre Résonance paramagnétique électronique Spectrométrie Stress oxydatif Toxicité Trouble fonctionnel Vasodilatateur coronarien Radical aryle Appareil respiratoire Iode Composé organique
- Keyword (en)
- Amiodarone Antianginal agent Antiarrhythmic agent Biosynthesis Epithelial cell Cytochrome c Reactive oxygen species Human In vitro Mitochondria Lung Free radical Electron paramagnetic resonance Spectrometry Oxidative stress Toxicity Dysfunction Coronary vasodilator agent Respiratory system Iodine Organic compounds
- Keyword (es)
- Amiodarona Antianginoso Antiarrítmico Biosíntesis Célula epitelial Citocromo c Especies reactivas del oxígeno Hombre In vitro Mitocondria Pulmón Radical libre Resonancia paramagnética electrónica Espectrometría Estrés oxidativo Toxicidad Trastorno funcional Vasodilatator coronario Aparato respiratorio Iodo Compuesto orgánico
- Classification
- Discipline
- Toxicology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20207748
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.taap.2007.12.009 
https://dx.doi.org/10.1016/j.taap.2007.12.009
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