Bax-mediated mitochondrial outer membrane permeabilization (MOMP), distinct from the mitochondrial permeability transition, is a key mechanism in diclofenac-induced hepatocyte injury : Multiple protective roles of cyclosporin A
- Autor
- WOEN PING SIU1 ; PUN, Pamela Boon Li1 ; LATCHOUMYCANDANE, Calivarathan1 ; BOELSTERLI, Urs A1 2 3
[1] Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117 597, Singapore
[2] Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore 117 597, Singapore
[3] Department of Pharmaceutical Sciences, University of Connecticut, Stows, CT 06269, United States - Fuente
Toxicology and applied pharmacology. 2008, Vol 227, Num 3, pp 451-461, 11 p ; ref : 1 p.1/2
- CODEN
- TXAPA9
- ISSN
- 0041-008X
- Campo Científico
- Pharmacology drugs; Toxicology
- Editor
- Elsevier, San Diego, CA
- País de la publicación
- United States
- Tipo de documento
- Article
- Idioma
- English
- Palabra clave de autor
- Bax Cyclophilin D Cyclosporin A Diclofenac Hepatotoxicity MOMP Mitochondria
- Palabra clave (fr)
- Analgésique Antiinflammatoire non stéroïde Antipyrétique Ciclosporine Diclofénac Foie Hépatotoxicité Immunodépresseur Membrane externe Mitochondrie Mécanisme action Pathologie du foie Peptidylprolyl isomerase Perméabilité Polytraumatisme Prévention Toxicité Inhibiteur de la calcineurine Appareil digestif Dérivé de l'acide arylacétique Enzyme Inhibiteur enzyme Isomerases Oxidoreductases Pathologie de l'appareil digestif Prostaglandin-endoperoxide synthase Traumatisme cis-trans-Isomerases
- Palabra clave (in)
- Analgesic Non steroidal antiinflammatory agent Antipyretic Ciclosporin Diclofenac Liver Hepatotoxicity Immunosuppressive agent External membrane Mitochondria Mechanism of action Hepatic disease Peptidylprolyl isomerase Permeability Multiple injury Prevention Toxicity Digestive system Arylacetic acid derivatives Enzyme Enzyme inhibitor Isomerases Oxidoreductases Digestive diseases Prostaglandin-endoperoxide synthase Trauma cis-trans-Isomerases
- Palabra clave (es)
- Analgésico Antiinflamatorio no esteroide Antipirético Ciclosporina Diclofenaco Hígado Hepatotoxicidad Inmunodepresor Membrana externa Mitocondria Mecanismo acción Hígado patología Peptidylprolyl isomerase Permeabilidad Politraumatismo Prevención Toxicidad Aparato digestivo Arilacético ácido derivado Enzima Inhibidor enzima Isomerases Oxidoreductases Aparato digestivo patología Prostaglandin-endoperoxide synthase Traumatismo cis-trans-Isomerases
- Clasificación
- Disciplina
- Toxicology
- Procedencia
- Inist-CNRS
- Base de datos
- PASCAL
- Identificador INIST
- 20207755
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DOI
10.1016/j.taap.2007.11.030 
https://dx.doi.org/10.1016/j.taap.2007.11.030
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